HOME >> BIOLOGY >> NEWS
Peering inside the body, with a new spinliterally

e resolution seen in stationary NMR.

But it's living tissue that holds the most promise for this method, Wind said, because there is no good way to see what is happening in many areas of the body, especially at the boundaries of organs and tissues and bone or air cavities such as lungs and sinuses. Here, the large magnet used in NMR generates small magnetic fields that broaden the spectral lines so much that information about those fine details is lost.

Wind's slow-spin technique, which can generate detailed spectra from these boundary regions, takes advantage of a quirk in NMR. NMR generates a spectral signature of compounds in a sample based on the frequencies of the sample's atomic nuclei as they jiggle in a strong magnetic field. NMR pioneers noticed more than a half-century ago that they could get better spectral resolution if they spun a sample at a 54.74-degree angle to the magnetic field. The faster they spun a sample oriented in this so-called magic angle, the more structural detail they obtained.

"This was very fast spinning, an ultra-centrifuge, thousands of rotations per second," Wind said. "If you tried that with intact tissue or a live animal, you'd blow up your bio-sample and kill the subject."

But what if you could slow the spinning down, so that a live animal could withstand the centrifugal force? The problem with slow MAS is that it produced unwanted signals, what Wind and colleagues call "spinning side bands," that obscured the sample's spectra.

Wind let the idea percolate for about six years as he worked on a combined NMR-optical microscope other devices at the W.R. Wiley Environmental Molecular Sciences Laboratory on PNNL's Richland, Wash., campus. When he came at the problem again, he brought reinforcements, most notably in the person of NMR expert and PNNL staff scientist Jian Z. Hu.

Working with Hu, Wind found he could get detailed spectra in biological samples at record-slow MAS speeds by us
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
14-Sep-2004


Page: 1 2 3

Related biology news :

1. Peering inside a blood vessel
2. Peering at a machine that pries DNA apart
3. Microbes found in Mayan ruins may deteriorate stone from inside out
4. Scripps scientists look deep inside sharks and their high-performance swimming system
5. IUB scientists to study the ecology of infectious disease -- inside ticks
6. 3-D imaging inside living organism, using quantum dots
7. Automated imaging of brain tissue, high-quality glimpses inside arteries
8. Heart disease among some Japanese may be due to sequencing variation inside a gene
9. Tiny bugs in mealybugs have smaller bugs inside them
10. Buffalo neuroimaging researchers studying multiple sclerosis from inside human brain
11. Farming inside forests hurts bird communities more than timber harvesting, study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... , June 2, 2016 ... Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & Other ... provider visiongain offers comprehensive analysis of the ... this market will generate revenues of $17.98 billion in ... acquired DVTEL Inc, a leader in software and hardware ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... mission to bring innovative medical technologies, services and solutions to the healthcare market. ... and implementation of various distribution, manufacturing, sales and marketing strategies that are necessary ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
Breaking Biology Technology:
Cached News: