HOME >> BIOLOGY >> NEWS
Peering inside the body, with a new spinliterally

e resolution seen in stationary NMR.

But it's living tissue that holds the most promise for this method, Wind said, because there is no good way to see what is happening in many areas of the body, especially at the boundaries of organs and tissues and bone or air cavities such as lungs and sinuses. Here, the large magnet used in NMR generates small magnetic fields that broaden the spectral lines so much that information about those fine details is lost.

Wind's slow-spin technique, which can generate detailed spectra from these boundary regions, takes advantage of a quirk in NMR. NMR generates a spectral signature of compounds in a sample based on the frequencies of the sample's atomic nuclei as they jiggle in a strong magnetic field. NMR pioneers noticed more than a half-century ago that they could get better spectral resolution if they spun a sample at a 54.74-degree angle to the magnetic field. The faster they spun a sample oriented in this so-called magic angle, the more structural detail they obtained.

"This was very fast spinning, an ultra-centrifuge, thousands of rotations per second," Wind said. "If you tried that with intact tissue or a live animal, you'd blow up your bio-sample and kill the subject."

But what if you could slow the spinning down, so that a live animal could withstand the centrifugal force? The problem with slow MAS is that it produced unwanted signals, what Wind and colleagues call "spinning side bands," that obscured the sample's spectra.

Wind let the idea percolate for about six years as he worked on a combined NMR-optical microscope other devices at the W.R. Wiley Environmental Molecular Sciences Laboratory on PNNL's Richland, Wash., campus. When he came at the problem again, he brought reinforcements, most notably in the person of NMR expert and PNNL staff scientist Jian Z. Hu.

Working with Hu, Wind found he could get detailed spectra in biological samples at record-slow MAS speeds by us
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
14-Sep-2004


Page: 1 2 3

Related biology news :

1. Peering inside a blood vessel
2. Peering at a machine that pries DNA apart
3. Microbes found in Mayan ruins may deteriorate stone from inside out
4. Scripps scientists look deep inside sharks and their high-performance swimming system
5. IUB scientists to study the ecology of infectious disease -- inside ticks
6. 3-D imaging inside living organism, using quantum dots
7. Automated imaging of brain tissue, high-quality glimpses inside arteries
8. Heart disease among some Japanese may be due to sequencing variation inside a gene
9. Tiny bugs in mealybugs have smaller bugs inside them
10. Buffalo neuroimaging researchers studying multiple sclerosis from inside human brain
11. Farming inside forests hurts bird communities more than timber harvesting, study suggests

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Peering inside the body with new spinliterally

(Date:4/16/2014)... memories improves during childhood, associated with structural changes ... and parietal cortices. New research from UC Davis ... this crucial time. Eventually, that could give insights ... into and during adolescence and affect memory, such ... the middle of the brain, the hippocampus plays ...
(Date:4/16/2014)... composed of Dr. Martin Prechtl, Leo Heim and their ... has discovered a new method of generating hydrogen using ... is of particular interest when it comes to fuel ... and mild hydrogen production using water and formaldehyde", have ... . , Among other applications, the new approach can ...
(Date:4/15/2014)... away in Hartford, Connecticut, a Puerto Rican community is ... that is so authentic it has caught the attention ... Gregory J. Anderson (University of Connecticut) took a close ... markets of Hartford and uncovered evidence that gives new ... using for years: home is in the kitchen. , ...
Breaking Biology News(10 mins):How kids' brain structures grow as memory develops 2The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3
(Date:1/15/2014)... device," Nobel laureate Herbert Kroemer famously observed, ... found at the junctures where layers of ... of nanotechnology, the interfaces between layers of ... applications in such high-tech favorites as spintronics, ... vast potential of these metal oxide interfaces, ...
(Date:1/15/2014)... Jan. 15, 2014   Niagara Thermal Products ... been selected by Buffalo BioBlower Technologies LLC ("B3") ... of its SBIR Phase 2 award from the ... only comprehensive air purification system that kills all ... pollutants, allergens and organic particulates.  In independent testing ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... company developing antibody-drug conjugates for cancer, today announced the ... Board of Directors. Dr Reynolds has over 20 years, ... as Chief Medical Officer at Seattle Genetics. ... time for Oxford BioTherapeutics, as the company completes its ...
(Date:1/15/2014)... -- A study has been launched to ... Formula 1 track could help to tackle the problem ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... by healthcare provider Simplyhealth. Telemetry technology, which ... the on-track performance of Vodafone McLaren Mercedes Formula 1 ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
Cached News: