HOME >> BIOLOGY >> NEWS
Peering inside the body, with a new spinliterally

e resolution seen in stationary NMR.

But it's living tissue that holds the most promise for this method, Wind said, because there is no good way to see what is happening in many areas of the body, especially at the boundaries of organs and tissues and bone or air cavities such as lungs and sinuses. Here, the large magnet used in NMR generates small magnetic fields that broaden the spectral lines so much that information about those fine details is lost.

Wind's slow-spin technique, which can generate detailed spectra from these boundary regions, takes advantage of a quirk in NMR. NMR generates a spectral signature of compounds in a sample based on the frequencies of the sample's atomic nuclei as they jiggle in a strong magnetic field. NMR pioneers noticed more than a half-century ago that they could get better spectral resolution if they spun a sample at a 54.74-degree angle to the magnetic field. The faster they spun a sample oriented in this so-called magic angle, the more structural detail they obtained.

"This was very fast spinning, an ultra-centrifuge, thousands of rotations per second," Wind said. "If you tried that with intact tissue or a live animal, you'd blow up your bio-sample and kill the subject."

But what if you could slow the spinning down, so that a live animal could withstand the centrifugal force? The problem with slow MAS is that it produced unwanted signals, what Wind and colleagues call "spinning side bands," that obscured the sample's spectra.

Wind let the idea percolate for about six years as he worked on a combined NMR-optical microscope other devices at the W.R. Wiley Environmental Molecular Sciences Laboratory on PNNL's Richland, Wash., campus. When he came at the problem again, he brought reinforcements, most notably in the person of NMR expert and PNNL staff scientist Jian Z. Hu.

Working with Hu, Wind found he could get detailed spectra in biological samples at record-slow MAS speeds by us
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
14-Sep-2004


Page: 1 2 3

Related biology news :

1. Peering inside a blood vessel
2. Peering at a machine that pries DNA apart
3. Microbes found in Mayan ruins may deteriorate stone from inside out
4. Scripps scientists look deep inside sharks and their high-performance swimming system
5. IUB scientists to study the ecology of infectious disease -- inside ticks
6. 3-D imaging inside living organism, using quantum dots
7. Automated imaging of brain tissue, high-quality glimpses inside arteries
8. Heart disease among some Japanese may be due to sequencing variation inside a gene
9. Tiny bugs in mealybugs have smaller bugs inside them
10. Buffalo neuroimaging researchers studying multiple sclerosis from inside human brain
11. Farming inside forests hurts bird communities more than timber harvesting, study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOG´s ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , ... Well Made Simple," and 23andMe , the leading ... better food choices.  Zipongo can now provide customers with ... preferences, health goals and biometrics, but also genetic markers ... choices. Zipongo,s personalized food decision support platform ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics ... The move comes after the company changed focus to making analytical tools for ... and our new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart ...
(Date:4/19/2017)... , ... April 19, 2017 , ... ... which makes educational webinars accessible to novices as well as experienced users, ... variables of commonly performed coagulation screening tests. , Hemostasis testing quality is ...
(Date:4/19/2017)... 19, 2017 Veracyte, Inc. ... it will report its first quarter 2017 financial ... 2017. Following the announcement, Veracyte,s management will host a live ... discuss the company,s financial results and business progress. ... may be accessed by visiting Veracyte,s website at  http://investor.veracyte.com . ...
(Date:4/18/2017)... Texas (PRWEB) , ... April 18, 2017 , ... For ... Research Associates, co-members in the VaxCorps vaccine consortium, were named one of the top ... finalist since the inception of this category; winning the award four times previously, and ...
Breaking Biology Technology:
Cached News: