HOME >> BIOLOGY >> NEWS
Peering inside the body, with a new spinliterally

e resolution seen in stationary NMR.

But it's living tissue that holds the most promise for this method, Wind said, because there is no good way to see what is happening in many areas of the body, especially at the boundaries of organs and tissues and bone or air cavities such as lungs and sinuses. Here, the large magnet used in NMR generates small magnetic fields that broaden the spectral lines so much that information about those fine details is lost.

Wind's slow-spin technique, which can generate detailed spectra from these boundary regions, takes advantage of a quirk in NMR. NMR generates a spectral signature of compounds in a sample based on the frequencies of the sample's atomic nuclei as they jiggle in a strong magnetic field. NMR pioneers noticed more than a half-century ago that they could get better spectral resolution if they spun a sample at a 54.74-degree angle to the magnetic field. The faster they spun a sample oriented in this so-called magic angle, the more structural detail they obtained.

"This was very fast spinning, an ultra-centrifuge, thousands of rotations per second," Wind said. "If you tried that with intact tissue or a live animal, you'd blow up your bio-sample and kill the subject."

But what if you could slow the spinning down, so that a live animal could withstand the centrifugal force? The problem with slow MAS is that it produced unwanted signals, what Wind and colleagues call "spinning side bands," that obscured the sample's spectra.

Wind let the idea percolate for about six years as he worked on a combined NMR-optical microscope other devices at the W.R. Wiley Environmental Molecular Sciences Laboratory on PNNL's Richland, Wash., campus. When he came at the problem again, he brought reinforcements, most notably in the person of NMR expert and PNNL staff scientist Jian Z. Hu.

Working with Hu, Wind found he could get detailed spectra in biological samples at record-slow MAS speeds by us
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
14-Sep-2004


Page: 1 2 3

Related biology news :

1. Peering inside a blood vessel
2. Peering at a machine that pries DNA apart
3. Microbes found in Mayan ruins may deteriorate stone from inside out
4. Scripps scientists look deep inside sharks and their high-performance swimming system
5. IUB scientists to study the ecology of infectious disease -- inside ticks
6. 3-D imaging inside living organism, using quantum dots
7. Automated imaging of brain tissue, high-quality glimpses inside arteries
8. Heart disease among some Japanese may be due to sequencing variation inside a gene
9. Tiny bugs in mealybugs have smaller bugs inside them
10. Buffalo neuroimaging researchers studying multiple sclerosis from inside human brain
11. Farming inside forests hurts bird communities more than timber harvesting, study suggests

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Peering inside the body with new spinliterally

(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin and stain ... 100x better detail than the industry standard. But ... microscopy methods, it needed another medium to measure its ... of reference because it represents the highest standard of ... earliest discovery days of Ultralight Histology was to reverse ...
(Date:5/4/2015)... 2015   Tocagen Inc. , a clinical-stage ... Tocagen,s ongoing investigational studies were presented at the 11 ... Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons ... in Washington, D.C. In ... with FDA and continues to advance towards initiation ...
(Date:5/1/2015)... 1, 2015  Northwest Biotherapeutics (NASDAQ: NWBO ) ... immune therapies for solid tumor cancers, announced today that ... tranche of a $40 million investment from Woodford investment ... invested $25 million in NW Bio on November 19, ... agreement with the Company for a further $40 million ...
(Date:5/1/2015)... , May 1, 2015 /CNW/ - Softchoice, a leading North American ... is the proud recipient of two Cisco® Partner Summit Country ... of the Year and Security Partner of the Year for ... taking place this week in Montreal . ... but two Cisco partner awards at this year,s conference," said ...
Breaking Biology Technology:Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3Softchoice recognized with two Country Awards at Cisco Partner Summit 2015 2
Cached News: