Penn Researchers Awarded $10 Million Grant To Study Link Between Genes And,,Hormone-Related Cancers

(Philadelphia, PA) -- Whether taken to counteract menopausal symptoms with hormone replacement therapy or as oral contraceptives to prevent pregnancy, external hormones can increase the risk of breast and uterine cancers. To advance the investigation of hormone-induced female cancers, researchers at the University of Pennsylvania School of Medicine have been awarded a five-year Program Project Grant by the National Cancer Institute totaling nearly $10 million. This study has been dubbed by the investigators as "WISE: Women's Insights and Shared Experiences."

While female hormones can be risk factors for select cancers, a woman's genetic make-up may also affect her response to hormone exposures and the development of hormone-sensitive cancers. "The study's main objectives are to identify who is genetically susceptible to developing breast and uterine cancers, and to determine whether the anti-estrogen steroid progestin can help offset the increased risk of uterine cancers when added to traditional hormone replacement therapy, which consists of estrogen alone," explains Brian L. Strom, MD, MPH, principal investigator of the study and Chair of the Department of Biostatistics and Epidemiology at Penn. "A better understanding of the interaction between hormones and genetic mechanisms will have a great impact on how female cancers are addressed."

The $9.9 million WISE study combines the expertise of pharmacoepidemiologists, genetic epidemiologists, and molecular biologists to examine the relationships among hormone exposures, inherited susceptibility, and the genetic consequences of these exposures in the development of hormone-sensitive female cancers. The study is composed of three inter-related projects; two of which are population-based to ensure representation of the entire population and to eliminate selection bias.

The two population-based projects involve the random selection of women diagnosed with breast or uterine cancer from the entire Phi

Contact: Diane Giaccone
University of Pennsylvania School of Medicine

Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... BALTIMORE, Md. (PRWEB) , ... October 11, 2017 ... ... for digital pathology, announced today it will be hosting a Webinar titled, “Pathology ... of  Advanced Pathology Associates , on digital pathology adoption best practices and how ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
Breaking Biology Technology:
Cached News: