HOME >> BIOLOGY >> NEWS
Penn study finds signs folic acid and Vitamin B12 may lessen some ill effects of SMA

NOTE: The text of this release was revised on 23 MAY 2001 at 12:00 ET US.

Scientist says clinical trials should test findings

Scientists have found evidence suggesting that the severity of spinal muscular atrophy (SMA) may be ameliorated by common vitamins.

The findings by researchers at the University of Pennsylvania School of Medicine, which are to be published Thursday in the journal Molecular Cell, suggest that folic acid and Vitamins B12 may limit the severity of symptoms that afflict SMA patients.

"We are not suggesting that this is a cure. But it may help," said Gideon Dreyfuss, PhD, Isaac Norris Professor of Biochemistry and a Howard Hughes Medical Institute Investigator at Penn, and principal author of the study. SMA afflicts one of every 6,000-to-10,000 people and is the leading genetic killer of children under the age of two. But its symptoms-muscle weakness and wasting-differ in severity from person to person across a range of debilitation that scientists still cannot explain fully.

Most SMA patients die in their infancy, but some SMA patients do not become wheel-chair bound before the age of 20, and still others can live relatively normally until late in life. Until now, this variability has been attributed to "genetic modifiers" but the present study raises the possibility that it is influenced, perhaps to a significant extent, by nutritional factors.

Individuals afflicted with SMA have a genetic deficiency in a protein called SMN (survival of motor neurons), which is a "housekeeping" protein required by all cells -- especially motor neurons, the nerve cells that control the activity of muscles. When the levels of the SMN protein are too low, motor neurons are the first cells to degenerate, in turn leaving the major muscle groups without the stimulation they need to be viable.

To perform its function, SMN interacts with numerous proteins in the cell, helping them create som
'"/>

Contact: Ellen O'Brien
ellen.obrien@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
24-May-2001


Page: 1 2 3

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Penn study finds signs folic acid and Vitamin may lessen some ill effects SMA

(Date:10/29/2014)... their hair as a consequence of chemotherapy will benefit ... scalp cooling technology that prevents hair loss. , The ... by global scalp cooling manufacturing company, Paxman Coolers, of ... of the University of Huddersfield. , The research will ... a background in the pharmacology of cancer treatment, which ...
(Date:10/29/2014)... is open for the Society of ... SIR 2015 is the one place where ... related health care professionals can come together ... and technologies being presented, discussed and tested. ... minimally invasive, image-guided medicine, SIR 2015 will ...
(Date:10/29/2014)... household and industrial products are in the environment – ... of them, scientists have yet to determine whether they ... toward doing that by estimating which substances people are ... in the ACS journal Environmental Science & Technology ... the risks to human health of any given substance ...
Breaking Biology News(10 mins):New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
(Date:10/30/2014)... 2014  Ardelyx, Inc. (NASDAQ: ARDX ... gastrointestinal and metabolic diseases, today announced that it ... Thursday, November 6, 2014. Following the announcement, the ... call and webcast at 4:30pm ET to review ... update. The live webcast can be ...
(Date:10/30/2014)... SoundConnect , an industry ... 365 end users the key to turning this ... by adding voice enablement and hybrid audio conferencing. ... a communication tool that includes presence, instant messaging ... O365 becomes a comprehensive unified communications solution. Adding ...
(Date:10/30/2014)... Whitehouse Laboratories has formally announced a major ... Package Test Capacity. Responding to growing demands from life ... in environmental chamber storage space that will enable a ... to be securely held on site at Whitehouse Labs. ... already taken place with the recent completion of a ...
(Date:10/30/2014)... Oct. 30, 2014 A new report, commissioned ... Practice, takes an in-depth look at Indiana,s ... have resulted over two different time frames: 1993 to ... view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as well ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5
Cached News: