Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps ...( transduction. The molecular mechan...)

transduction. The molecular mechanism by which STK11 controls cellular differentiation in the gastrointestinal tract and in other organs is currently unknown. The search for physiological STK11 substrates will yield further insights into the complicated intracellular network of molecules that prevents the development of hamartomatous and preneoplastic lesions in various tissues.

The Peutz-Jeghers syndrome can now be diagnosed at the molecular genetic level. Atypical forms of this syndrome without the classical hallmark of pigment spots during the first two decades of life probably exist and can now be identified. A special screening program for individuals with mutations in the STK11 gene is highly recommended to detect early stages of potentially malignant tumors. The ultimate aim in this field of research is to identify drugs that reduce the extent of polyp formation and cancer risk.

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Contact: Dieter Jenne
djenne@alf.biochem.mpg.de
+49-89-8578-3588
Max-Planck-Gesellschaft
1-Jan-1998

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