HOME >> BIOLOGY >> NEWS
Phages point the way to novel targets for antimicrobial drug discovery

MONTREAL, QUBEC (September 15, 2003): By discovering and exploiting the targets that bacteriophages, or bacterial viruses, attack to inhibit microbial growth, scientists at PhageTech Inc. have identified novel small molecule compounds that effectively kill or inhibit the growth of disease-causing bacteria. The PhageTech researchers presented their work this week at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Chicago, Illinois.

"Over billions of years of evolution, bacteriophages, or "phages," have selected a variety of unique proteins that enable them to inhibit the growth of and kill bacteria in diverse ways," said Jinzi J. Wu, M.D., Ph.D., Phagetech vice president, R&D biology. "PhageTech has identified and exploited these phage-derived antimicrobial proteins as tools to discover novel bacterial targets essential to bacterial growth. Subsequent screening against these targets has now identified several small molecule compounds that appear to mimic the phage-derived inhibitory proteins in their antimicrobial effects, and further evaluation and development of these compounds as potential new antibiotics is underway."

PhageTech researchers first used high-throughput phage genomics and functional genomics strategies to sequence the genomes of 43 phages that infect three of the most important human pathogens: Staphylococcus aureus, Streptococcus pneumoniae and Pseudomonas aeruginosa. The scientists then identified the inhibitory proteins produced by these phages, and used them as "bait" to systematically identify the bacterial targets with which the phage proteins interacted. The result was the discovery of a variety of novel bacterial targets that were biologically validated by the phages and shown to be essential to bacterial growth. The researchers are still screening libraries of small molecule compounds against the newly identified targets for drug-like compounds that effectively inhibit or k
'"/>

Contact: Joan Kureczka
JKureczka@aol.com
415-821-2413
Kureczka/Martin Associates
14-Sep-2003


Page: 1 2

Related biology news :

1. Hunt for a new plant hormone points to carotenoids
2. DNA tests point to extinction of 2 distinctive arctic bird populations
3. Scientists pinpoint molecules that generate synapses
4. University of Chicago scientists pinpoint cellular cause of SIDS
5. Gene alteration points to longevity, thinness
6. VA/UCLA researchers pinpoint role of histamines in waking
7. Gene maps of simpler life forms point the way to human disease gene
8. Research points to potential obesity treatment
9. Study points to a promising new test for myelodysplasia, a blood disorder often leading to leukemia
10. Study points to possible cause of asthma exacerbations
11. Johns Hopkins gene hunters pinpoint new cancer gene target

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans to ... and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. ... Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , The ...
(Date:6/6/2019)... ... June 05, 2019 , ... MedTech ... the global health and medical technology market, announced that it has selected Medacta ... Robotics Solution” award in the 2019 MedTech Breakthrough Awards program. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, a global leader ... the new President of Molecular Devices, replacing Greg Milosevich who has been appointed ... , Since joining Molecular Devices in a scientific engineering role, Ms. Murphy has ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary ... of cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of ... cells with engineered T cell receptors known as “CARs”. The CAR enables the final ...
(Date:5/22/2019)... ... 22, 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation ... round co-led by Astanor Ventures and Talis Capital with participation ... iSelect Fund . The company has raised $11.75m to date and will use the ...
(Date:5/14/2019)... Calif. (PRWEB) , ... May 14, 2019 , ... ... office expansion, effectively doubling its space from 2,500 to 5,000 square feet. , ... Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home ...
(Date:5/2/2019)... BELTSVILLE, Md. (PRWEB) , ... ... ... certification to the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA ... consistently meet customer requirements. In addition, REPROCELL USA Inc. aims to enhance ...
Breaking Biology Technology:
Cached News: