Preti and Wysocki are now looking at the several dozen individual compounds that make up male perspiration to determine which may be responsible for the effects they observed. They also plan to study whether female pheromones can affect men's moods or physiological functions.
"This may open the door to pharmacological approaches to manage onset of ovulation or the effects of premenstrual syndrome or even natural products to aid relaxation," Wysocki said. "By determining how pheromones impact mood and endocrine response, we might be able to build a better male odor: molecules that more effectively manipulate the effects we observed."
The underarm extracts used in the study came from men who bathed with fragrance-free soap and refrained from deodorant use for four weeks. The extracts were blended to avoid reactions to individual men's odors. None of the women involved in the study discerned that male sweat had been applied right under their noses; some believed they were involved in a study of alcohol, perfume or even lemon floor wax.
Half the women received three applications of the male secretions during a six-hour period, followed three controlled exposures to ethanol, used as a control substance, over a six-hour period. For the other half, the regimen was reversed. The women did not report feeling any more or less energetic, sensuous, tired, calm, sexy, anxious, fatigued or active after exposure to male perspiration.
Preti and Wysocki are joined in the Biology of Reproduction paper by co-authors Kurt T. Barnhart and Steven J. Sondheimer of Penn's Department of Obstetrics and Gynecology and James J. Leyden of Penn's Department of Dermatology. Their work is sponsored by the National Institutes of Health.
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Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
14-Mar-2003