Pig-human transplantation not PERVerted

Organ or tissue transplantation is a potentially life-saving measure for millions of individuals who have suffered organ failure or require tissue grafts for a variety of reasons. Today thousands die while waiting for suitable organs or tissues to become available. One potential means for relieving this shortage has been through xenotransplantation, that is to use organs or tissues from other organisms, such as pigs.

A major concern of xenotransplantation is the possibility of transmitting pathogens from these other species into the donor. Particular attention, for the case of transplantation of tissues and organs from pigs, has been paid to a set of pig-derived viruses called PERVs (for Porcine Endogenous RetroViruses) because they possess the ability, though limited, to replicate in human cells. So far, the actually frequency of PERV transmission within a living organism has not been tested in either patients or animal models under circumstances where human cells are exposed over a long term to similar amount of pig tissue.

Yong-Guang Yang and colleagues, from Massachusetts General Hospital/Harvard Medical School, provide new data that indicate the dangers of such viral transmission may be extremely low and that pigs may be a safer source of transplantation material than previously thought. To carry out their assessment, the researchers developed a new xenotransplantation model where human cells coexist with large numbers of porcine cells in a transgenic mouse.

The study showed that these cells could in fact coexist long-term without PERV infection in the human cells. Although, the authors did find that human cells in these mice did contain PERV sequences, further investigation proved that this was the result of a mouse retrovirus infecting the pig cells and then transmitting the PERV from there to the human cells. This is not a concern in actual xenotransplantation, but intriguingly may account for previous observations of PERV transmission into hu

Contact: Laurie Goodman
Journal of Clinical Investigation

Page: 1 2

Related biology news :

1. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
2. Cells from adult bone marrow can be converted into brain stem cells for transplantation
3. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
4. Hopkins researchers identify transplantation antigens among Sioux Indians
5. Transparent fish provide window on blood formation and marrow transplantation
6. Immerge BioTherapeutics announces new findings addressing key safety risk in xenotransplantation
7. Cell transplantation could restore cardiac function after heart attack
8. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
9. Islet cell transplantation for diabetes turns corner
10. 1st evidence that nuclear transplantation (therapeutic cloning) can eliminate tissue rejection
11. Improvement in some patients who underwent neuronal transplantation following stroke, according to study by University of Pittsburgh researchers

Post Your Comments:

(Date:10/22/2019)... (PRWEB) , ... October 21, 2019 , ... Join ... MS, Director of Bioanalytical in a live session on Thursday, October 31, ... CRO partner. , A good CRO partner should have expertise in method development, ...
(Date:10/17/2019)... (PRWEB) , ... October 15, 2019 , ... ... Prepared Media for the Microbiological Community”. , Microbiology International currently manufactures ready-to-use culture ... company also offers pre-poured agar plates & liquid supplements. , This major step ...
(Date:10/15/2019)... ... 2019 , ... Erchonia, the global leader in the manufacturing ... in Orlando & 18th Annual Golf Tournament. The invite-only, four-day event starts ... Melbourne. , The first day will kick off with training and roundtable discussions ...
Breaking Biology News(10 mins):
(Date:10/22/2019)... , ... October 22, 2019 , ... nQ Medical, Inc. ... School’s 2019 Most Fundable Companies List which was announced at a showcase event yesterday ... million in annual revenue, strong business plans, and impressive near-term growth projections to be ...
(Date:10/22/2019)... N.J. (PRWEB) , ... October 22, 2019 , ... Catalent, ... Clinical Supply Services and Drug Product Technologies Integration, will participate in a panel session ... Conference (HPCLC), to be held at the Gwen Hotel, Chicago, on Oct. 28-30, 2019. ...
(Date:10/22/2019)... LOS ANGELES (PRWEB) , ... October 22, 2019 ... ... software provider, today announced integration of the Alertus Mass Notification System into its ... critical infrastructure to the Enplug platform, making it possible for users to leverage ...
(Date:10/22/2019)... ... , ... DermBiont, a clinical stage microbiome biotechnology company developing ... safety endpoints, with no application site reactions and no adverse events, in a ... tinea pedis (athlete’s foot). Additionally, the trial demonstrated a clinical response with improvement ...
Breaking Biology Technology:
Cached News: