Pinpoint Gene Control Holds Promise For Nervous System Studies

Scientists have taken their control over genes one step further by developing a technology to turn on or off a gene in the adult nervous system whenever and wherever they want. Scientists at the University of Rochester report in the January issue of Nature Biotechnology on the first demonstration of the technology: permanently turning on in adult mice the gene for nerve growth factor (NGF), a substance that has been difficult for scientists to study because it's so difficult to manipulate.

Investigators believe the method will make possible important studies into the way our nervous system works. "This technology gives us an unprecedented opportunity to study the function of nearly any gene in the nervous system," says principal investigator Howard Federoff, M.D./Ph.D., chief of the University of Rochester's Division of Molecular Medicine and Gene Therapy.

"The most ideal way to study a gene is to have the ability to turn on or off that gene at any time that you wish, at any place that you wish. This new approach allows us this level of control."

Graduate student Andrew Brooks is first author of the paper. Also contributing were scientist Nariman Panahian, research associate Bhaskar Muhkerjee, and Professor Deborah Cory-Slechta, Ph.D. Brooks presented the work, which is funded by the National Science Foundation, at last month's Society for Neuroscience meeting in Washington.

The Rochester team used a new type of genetic surgery to carry out the experiment. First they created a special strain of mice by inserting extra NGF genes into their DNA, along with a "stop" DNA sequence that kept the genes turned off. Then, when the mice were several months old, scientists injected a viral vector that shuttled into the cells an enzyme that snipped out the "stop" sequence, activating the extra genes to produce NGF. The team believes this is the first permanent genetic modification in the central nervous system of an adult mammal.


Contact: Tom Rickey
University of Rochester

Page: 1 2 3

Related biology news :

1. Pinpointing viruses in body scans
2. Pinpointing the mutations that cause resistance to Gleevec
3. Pinpointing the protein problem in Lou Gehrigs Disease
4. Pinpoint targeting promises improved success in gene therapy for blood and other disorders
5. UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
6. Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say
7. Williams Syndrome: UD Research Pinpoints Language And Learning Traits Of Those With The Disorder
8. Alcoholics Adversary: Study Pinpoints Brain Molecule That Is Key For Alcohol Preference And Sensitivity
9. Study Pinpoints Rare Molecular Transitions As Possible Cause Of Skin Photoaging
10. New Imaging Technique Pinpoints Dead Heart Muscle
11. Researchers Pinpoint Site For Petit Mal Seizures In Brain

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: