Pinpointing the mutations that cause resistance to Gleevec

Researchers have identified specific mutations in a rogue gene that render the drug Gleevec ineffective in patients who have chronic myeloid leukemia.

The studies could provide new information that may improve the effectiveness of second-generation drugs for chronic myeloid leukemia (CML). The researchers said their findings suggest that these mutations are central to resistance to Gleevec observed in some patients with CML.

CML develops when an enzyme called Abelson tyrosine kinase (Abl) becomes overactivated by a chromosomal mixup that occurs during blood cell development. The genes ABL and BCR, which are located on different chromosomes, become fused and express a hybrid Bcr-Abl enzyme that is always active. The abnormal activity of the enzyme causes the overproliferation of white blood cells that is the hallmark of CML.

In an article published in the August 2002 issue of the journal Cancer Cell, researchers led by Charles Sawyers at the University of California, Los Angeles, and Howard Hughes Medical Institute (HHMI) investigator John Kuriyan at the University of California, Berkeley, reported that they identified 15 mutations in the BCR-ABL gene that cause resistance to Gleevec. Sawyers was selected as an HHMI investigator in May 2002 in a national competition to identify outstanding investigators who are conducting patient-oriented research.

The latest findings build on earlier work by Sawyers' group that showed that mutations in BCR-ABL underlie resistance to Gleevec, a drug that has shown remarkable potency against CML. "We had studied a handful of CML patients who had a beautiful initial response to Gleevec, but who then relapsed quite dramatically," Sawyers said. "Our biochemical studies showed that the Bcr-Abl target protein, which was inhibited when the patients responded to the drug, was turned back on. Then, we found in

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3 4

Related biology news :

1. Pinpointing viruses in body scans
2. Pinpointing the protein problem in Lou Gehrigs Disease
3. Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say
4. Genetic mutations linked to the practice of burning coal in homes in China
5. Rare mutations can significantly increase risk factor for heart disease
6. The mother lode of mutations
7. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
8. Yeast mutations offer window into human disease
9. Ancient DNA mutations permitted humans to adapt to colder climates, UCI researchers find
10. BRCA mutations not associated with colorectal cancer risk, studies suggest
11. BRCA mutations do not increase risk of colorectal cancer

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: