HOME >> BIOLOGY >> NEWS
Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders

PITTSBURGH, Dec. 18 -- Like a car that transports its passengers, layers of lipids form a protective barrier for their passenger DNA molecules, safely whisking them past DNA-degrading enzymes and quickly delivering them to their destinations, or target cells.

A research team from the University of Pittsburgh has constructed the first prototype of this "car," a delivery mechanism for genes called a reconstituted chylomicron remnant (RCR) that has resulted in the extended production of therapeutic proteins in an animal model, according to a report published in the Dec. 23 Proceedings of the National Academy of Sciences.

The research was developed in collaboration with Targeted Genetics Corporation, Seattle, and the RCR Vector is exclusively licensed to Targeted Genetics.

In the study, Pitt researchers detailed how they coated twisted strands of DNA encoding for the a1-antitrypsin (hAAT) gene with lipids and added oil to form stable RCR structures with 65 percent of DNA incorporated into the oil core.

"We have developed the first non-viral vector that resembles a naturally occurring lipoprotein," stated Leaf Huang, Ph.D., professor of pharmacology at the University of Pittsburgh. Typically, lipoproteins pick up fat and take it to the liver where it is released and processed.

"In our studies, we placed genes into the RCR structures instead of fat and found that these genes were released into liver cells and their blueprints were used to build new proteins," added Dr. Huang. "Mimicking the body's own transport system, we have created a model in which we have used a good copy of hAAT to show that RCRs are a great way to get genes into cells and direct the body's cellular machinery to produce therapeutic proteins." A bad copy of the hAAT gene is thought to cause pulmonary emphysema and liver disease. Introducing a good copy into target cells
'"/>

Contact: Amy Kemp
kempam@a1.isd.upmc.edu
(412) 624-2607
University of Pittsburgh Medical Center
22-Dec-1997


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. Crystallography ... X-ray analysis community, presenting current news and crystallographic research. , The latest ...
(Date:8/12/2020)... Mich. (PRWEB) , ... August 11, 2020 , ... ... R&D subsidiary based in Princeton, NJ, have entered into license agreements with Housey ... and development. Both Roche and J&J have annual Research and Development spending ...
(Date:8/3/2020)... ... , ... Accumen Inc. is helping healthcare get better, faster. ... to provide COVID-19 saliva testing kits nationally. , “Accumen has been partnering ... years. Early in the COVID-19 crisis, we identified supply chain gaps and began ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT ... Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: ... hosted an elite awards program, highlighting outstanding examples of how technology innovations and ...
(Date:6/28/2020)... JOSE, Calif. (PRWEB) , ... June 25, 2020 ... ... globe, researchers are racing to develop a vaccine or drug treatment. In an ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic ...
Breaking Biology Technology:
Cached News: