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Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon

ng significant advances in understanding animal models of autoimmune diseases using magnetic resonance microscopy (MRM). Used to study living animals, MRM provides near cellular detail of internal organs. Center scientists are developing quantitative methods to perform "virtual" pathologic analyses of diseased brain tissues with MRM. These analytical tools will unambiguously discriminate between nerve destruction caused by MS and other types of neurological injury that often appear indistinguishable using conventional MRI. Project scientists also will design MRM methods to track immune cells inside animals to understand the role these cells play in autoimmunity. Given its promise, MRM could one day provide an important tool for pre-clinical drug testing for diseases such as MS.

  • Quantitative Perfusion Imaging. Adequate blood flow is crucial for proper maintenance of normal metabolic and physiologic states in animals and humans. MRI offers an excellent, non-invasive, method to measure the blood flow through tissue and organs. NMR Center investigators are exploring new methods to accurately measure blood flow, which may be used to assess organ function and health.
  • MR Bioimaging Methodologies for Monitoring Function of Transplanted Organs. Center investigators are exploring ways to process MRI signals to provide an extensive non-invasive report on how a transplanted organ functions. MRI research performed to date has revealed new aspects of transplanted kidney function in laboratory animals, providing an excellent foundation to establish advanced MRI methods to monitor transplanted organ functions non-invasively in patients.
  • High Resolution Dynamic Imaging. Center investigators are exploring ways to increase the speed and sensitivity of MRI methods, which is fundamental to advancing MRI in research and clinical settings.
  • The grant also supports five collaborative research projects and a number of s
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    Contact: Lauren Ward
    wardle@andrew.cmu.edu
    412-268-7761
    Carnegie Mellon University
    15-Mar-2004


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