HOME >> BIOLOGY >> NEWS
Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model

PITTSBURGH, Dec. 4 -- Research by scientists at the University of Pittsburgh School of Medicine and the Graduate School of Public Health (GSPH) in collaboration with colleagues at the Centers for Disease Control and Prevention (CDC) in Atlanta has shown that an adenoviral-based vaccine can induce SARS-coronavirus (SARS-CoV)-specific T-cell and virus-neutralizing antibody responses.

The study, which represents the first published work on the development of a SARS vaccine and comes only a few months after the SARS coronavirus was identified and its genome was sequenced, is reported in a fast track research letter in the Dec. 6 issue of The Lancet.

"It is our hope that this research will lead to a protective vaccine against SARS," stated project leader Andrea Gambotto, M.D., from the departments of surgery and medicine, division of infectious diseases and the Molecular Medicine Institute (MMI) at the University of Pittsburgh School of Medicine.

In the study, researchers immunized six rhesus macaques intramuscularly with a combination of three SARS-CoV vectors. Two additional macaques were immunized with the same amount of empty adenoviral vector and served as controls. After 28 days, the animals received a second vaccination. Six weeks after vaccination, T-cells and antibodies against SARS were detected in all six of the immunized animals, but not in either of the control animals. The intensity of the response varied among animals but was generally largest after the booster vaccination, according to the Pittsburgh researchers. Serum samples from the vaccinated animals, but not from the controls, showed strong neutralizing capacity against SARS-CoV.

"From a scientific perspective, several points are important. We obtained the recombinant vaccine by engineering a common cold virus to express the SARS coronavirus antigens. This is a successful strategy that we are exploring for other infectious diseases such as HIV," said Dr. Gambott
'"/>

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
4-Dec-2003


Page: 1 2 3

Related biology news :

1. University of Pittsburgh receives $10 million grant for head and neck cancer
2. University of Pittsburgh medical center among first to implant heart assist device
3. University of Pittsburgh receives NIH funding to develop heart assist device for infants
4. Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon
5. University of Pittsburgh Medical Center acquires biotechnology firm Rheogene Inc.
6. Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
7. University of Pittsburgh scientist honored for major accomplishment in cancer research
8. Worlds largest scientific society to hold regional meeting in Pittsburgh
9. University of Pittsburgh named cooperative research center for muscular dystrophy
10. Infectious disease study findings presented by University of Pittsburgh scientists
11. University of Pittsburgh study links gynecological complaint to increased risk for herpes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years old when her ... elbow dysplasia, which caused painful osteoarthritis in the joints. She was referred to ... heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the multi-platform ... announces the launch of version 13.1. The new version extends FileWave’s mobile device ... supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s version 13 that ...
(Date:5/26/2019)... ... 24, 2019 , ... Zolgensma (Novartis, AveXis), an AAV-delivered gene therapy used to ... in the United States by the Food and Drug Administration today. , ... genetic disorders in the United States and the second-ever approved treatment for SMA. , ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A study released today ... system for the sustained release of human placental stem cell (HPSC)-derived conditioned medium ... to deliver CM into the injured kidney, where it helped restore function and ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ ... The redesigned website aims to improve LDA’s ability to communicate directly with the ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the ... ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) protocol ... that 6.3 million Americans will have glaucoma, with black Americans having the highest ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... the greater Boston area. Gone are the days of painful hair transplant procedures. ... Hair Restoration System is the only robotic intelligent solution to offer a minimally ...
Breaking Biology Technology:
Cached News: