HOME >> BIOLOGY >> NEWS
Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model

PITTSBURGH, Dec. 4 -- Research by scientists at the University of Pittsburgh School of Medicine and the Graduate School of Public Health (GSPH) in collaboration with colleagues at the Centers for Disease Control and Prevention (CDC) in Atlanta has shown that an adenoviral-based vaccine can induce SARS-coronavirus (SARS-CoV)-specific T-cell and virus-neutralizing antibody responses.

The study, which represents the first published work on the development of a SARS vaccine and comes only a few months after the SARS coronavirus was identified and its genome was sequenced, is reported in a fast track research letter in the Dec. 6 issue of The Lancet.

"It is our hope that this research will lead to a protective vaccine against SARS," stated project leader Andrea Gambotto, M.D., from the departments of surgery and medicine, division of infectious diseases and the Molecular Medicine Institute (MMI) at the University of Pittsburgh School of Medicine.

In the study, researchers immunized six rhesus macaques intramuscularly with a combination of three SARS-CoV vectors. Two additional macaques were immunized with the same amount of empty adenoviral vector and served as controls. After 28 days, the animals received a second vaccination. Six weeks after vaccination, T-cells and antibodies against SARS were detected in all six of the immunized animals, but not in either of the control animals. The intensity of the response varied among animals but was generally largest after the booster vaccination, according to the Pittsburgh researchers. Serum samples from the vaccinated animals, but not from the controls, showed strong neutralizing capacity against SARS-CoV.

"From a scientific perspective, several points are important. We obtained the recombinant vaccine by engineering a common cold virus to express the SARS coronavirus antigens. This is a successful strategy that we are exploring for other infectious diseases such as HIV," said Dr. Gambott
'"/>

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
4-Dec-2003


Page: 1 2 3

Related biology news :

1. University of Pittsburgh receives $10 million grant for head and neck cancer
2. University of Pittsburgh medical center among first to implant heart assist device
3. University of Pittsburgh receives NIH funding to develop heart assist device for infants
4. Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon
5. University of Pittsburgh Medical Center acquires biotechnology firm Rheogene Inc.
6. Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
7. University of Pittsburgh scientist honored for major accomplishment in cancer research
8. Worlds largest scientific society to hold regional meeting in Pittsburgh
9. University of Pittsburgh named cooperative research center for muscular dystrophy
10. Infectious disease study findings presented by University of Pittsburgh scientists
11. University of Pittsburgh study links gynecological complaint to increased risk for herpes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of ... board-certified in surgery and surgery of the hand by the National Board of ... to going above and beyond in his pursuit of providing the most comprehensive, ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on ... that Charles W. Stellar has been named by the WEDI Board of Directors as ... As an executive leader with more than 35 years of experience in healthcare, association ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that ... wound healing and tissue regeneration. , The novel method, developed by WPI faculty ...
(Date:5/24/2016)... Maryland (PRWEB) , ... May 24, 2016 , ... ... of a newly re-branded identity. The new Media Cybernetics corporate branding reflects a ... world of imaging and image analysis. The re-branding components include a crisp, refreshed ...
Breaking Biology Technology:
Cached News: