HOME >> BIOLOGY >> NEWS
Plakin proteins brace nerve axons and allow for the transport of neurotransmitter vesicles

Without nuts and bolts, bridges and buildings would be nothing more than piles of beams and girders. Like skyscrapers, cells have internal support systems, but instead of steel, cells use a variety of rod-like protein fibers for their microscopic cytoskeletons.

At the University of Chicago, scientists interested in skin disorders caused by a weakening of the cytoskeleton have long known that a group of bolt-like proteins called plakins, brace the intermediate filaments. Of the three filamentous systems of the cytoskeleton, intermediate filaments have a diameter that places them between the microfilaments (think of them as high tension wires) and microtubules (the I-beam of the cell).

Now, researchers led by Elaine Fuchs, PhD, Amgen Professor of Molecular Genetics & Cell Biology and Howard Hughes Investigator, report in the July 23 issue of Cell, that plakins bind to all three components of the cytoskeleton, providing an integrated bracing system that gives cells their strength and flexibility.

This important finding sheds new light on how nerve axons, which in humans can reach as much as a meter in length for a single neuron, maintain their rigidity and allow for the transport of neurotransmitter-filled vesicles from one end to the other.

"We have known for several years that plakins give intermediate filaments their mechanical strength by anchoring them to the actin cytoskeleton just inside the cellular membrane, and that plakins also can stabilize intercellular junctions by linking them to the cytoskeleton," says Fuchs "But now we are seeing how truly versatile these fascinating plakin proteins are in that some of them can bind to and stabilize microtubules."

An important component of the cytoskeleton, microtubules serve as the cellular highway for the transport of vesicles and other proteins. "Stabilizing microtubules is especially important for cells like neurons which need to transport vesicles over very long distances," Fuchs
'"/>

Contact: Sharon Parmet
sparmet@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
23-Jul-1999


Page: 1 2 3

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. New dye directly reveals activated proteins in living cells
3. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
4. Scientists discover proteins involved in spread of HIV-1 infection
5. New mechanism for display of foreign proteins to immune system
6. Scientists visualise cellular handmaiden that restores shape to proteins
7. Hopkins scientists use blood proteins to detect ovarian cancer
8. Viral proteins may prevent bacterial infections
9. Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
10. Good bacteria trigger proteins to protect the gut
11. Harmless virus helps slow HIV by boosting immune proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2019)... GALWAY, Ireland (PRWEB) , ... April 02, 2019 ... ... discovery, development and commercialization of first-in-class stromal cell immunotherapies, announced it will move ... to become the anchor tenant at the University’s newly created biotechnology park in ...
(Date:4/4/2019)... ALISO VIEJO, Calif. (PRWEB) , ... April 02, ... ... a leading clinical genetics testing company, will present results demonstrating that RNA genetic ... hereditary cancer genetic testing. This study, awarded as a Top Rated poster, is ...
(Date:4/1/2019)... ... April 01, 2019 , ... uBiome announces ... Related Conditions” by the US Patent and Trademark Office on January 1, 2019 ... by uBiome collaborators Dr. Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, ...
Breaking Biology News(10 mins):
(Date:4/10/2019)... , ... April 10, 2019 , ... After more than ... The new kitchen is equipped with updated appliances and modern lighting and fixtures, ... Jolla-based venue. , “We’ve seen tremendous growth in the demand for our ...
(Date:4/9/2019)... ... , ... Sonny Bar Lisa, or Sonny for short, is a quarter horse ... a series of diagnostics, an MRI was performed which revealed Sonny had torn his ... found that VetStem Regenerative Cell Therapy may be a treatment option for ...
(Date:4/8/2019)... and BOSTON (PRWEB) , ... April 08, 2019 ... ... cloud-based enterprise-class unified communications and collaboration solutions, announced today the launch of their ... to an unprecedented range of business and contact-orientated applications while using CT Cloud ...
(Date:4/8/2019)... ... April 09, 2019 , ... To support the global ... Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to help them analyze and ... Biohub’s efforts to establish new approaches to inform the discovery of antibody-based diagnostics, ...
Breaking Biology Technology:
Cached News: