Plant-Based Therapies Examined For Colon Cancer Prevention

Three therapies derived from plants will be tested at The Rockefeller University in New York City for their ability to prevent colorectal cancer, which afflicts some 150,000 Americans each year. The compounds have the potential to be safer than cancer-thwarting nonsteroidal antiinflammatory drugs (NSAIDs), widely used aspirin-like drugs known to prevent colorectal cancer as well as reduce related deaths by half.

Eating diets rich in fruits and vegetables helps reduce the risk of colorectal cancer as well as deaths from the disease, according to population-based studies. However, the chemicals in these plants responsible for the anti-cancer effect are not well known. "Certain plant-derived compounds called phenolics act similarly to NSAIDs in hindering cancer, yet may lack their bad side effects such as irritating the stomach lining or damaging the liver or kidneys," says Steven J. Shiff, M.D., assistant professor in the Laboratory of Human Behavior and Metabolism at Rockefeller. "If as effective or better than the drugs, these plant therapies might be much better tolerated for longer periods of time than NSAIDs."

In the study, Shiff and his colleagues will compare three plant-derived compounds, curcumin, rutin and quercetin, to the NSAID sulindac. The study will determine whether these naturally occuring chemicals, all potent antioxidants and antiinflammatories, can affect cells in a similar manner as sulindac, which prompts the cells to "turn on" a program of regulated cell death called apoptosis. NSAIDs, which include ibuprofen and naproxen, are among the most commonly used therapies worldwide for relieving pain and inflammation in joints and muscles.

Curcumin, notes Shiff, has been used for centuries as an antiinflammatory agent. The compound is the pigment that gives the yellow color to the seasoning curry, mustard and turmeric, the powdered form of the root of Curcuma longa Linn. Curcumin is an approved additi

Contact: Marion E. Glick or Joseph Bonner
Rockefeller University

Page: 1 2 3

Related biology news :

1. Plant-Based Fat Inhibits Growth Of Breast-Cancer Cell Line, UB Researchers Show
2. Plant-Based Fat May Reduce Risk Of Prostate Cancer By Altering Testosterone Metabolism, UB Study Shows
3. Plant-Based Fat Inhibits Cancer-Cell Growth By Enhancing Cells Signaling System, UB Researchers Show
4. Image-guided Therapies
5. New Anti-HIV Therapies Needed To Eradicate HIV
6. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
7. Genetically Engineered Mice Show Characteristic Signs Of Alzheimers, Could Be Ideal Tool For Testing New Therapies
8. Penn Researchers Prove "Short-Cut" Function Of Myelin Sheath Channel: BetterUnderstanding Of Myelin Should Lead To Therapies For Neuropathies
9. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies
10. Harvard Medical School Researchers Identify Four Human Genes Essential To Cell Division; Discovery Yields New Target For Cancer Therapies
11. Novel AIDS-Directed Technology: Approach Permits Optimization Of Existing Drug Therapies And Targeted, Patient-Specific Treatment

Post Your Comments:

(Date:8/26/2020)... , ... August 25, 2020 , ... Modality Solutions, ... Inc. magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking ... 2019 as well, and for this year’s list, reported three-year revenue growth of 71 ...
(Date:8/21/2020)... ... August 20, 2020 , ... ... Movahhed , a Clinical Operations executive with expertise in clinical trial planning and ... firm as an Expert Consultant. Throughout his career, Mr. Movahhed has helped design ...
(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid Services ... jelly allografts to be assigned a Q code and be approved for application directly ... allograft product to be recognized as a 361 HCT/P by CMS regulated under 21CFR ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... SHREWSBURY, Mass. (PRWEB) , ... July 29, 2020 ... ... clad wire that can combine up to three different materials for use with ... can combine up to three materials to meet specific design requirements, performance, and ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... 200 of the top radiation centers in 16 countries, has reached its 20th ... SDX® is now in routine use at top universities including University of Pennsylvania, ...
(Date:7/18/2020)... , ... July 16, 2020 , ... After research model ... completion of a great surgery is only the beginning of a successful study, while ... community. , Join Brad Gien, Global Head of Surgery from Envigo in ...
Breaking Biology Technology:
Cached News: