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Plastic tube may help treat paralysis

CHICAGO, August 28 Canadian researchers have created a plastic tube that fits around the spinal cord and restores some movement in paralyzed rats, according to research presented at the 222nd national meeting of the American Chemical Society, the worlds largest scientific society. The researchers say the work could lead to a new treatment for paralysis in humans.

Rats whose spinal cords had been cut walked somewhat better eight weeks after a plastic tube filled with chemicals that promote nerve growth was implanted in their spine. We know the rats improved. What we have to do now is figure out how significant the improvement is, said lead researcher Molly Shoichet, Ph.D., an associate professor at the University of Toronto. Shoichet, who has studied 80 rats to date, cautions that significantly more work needs to be done with animals before the treatment can be tested in people.

On a common test of paralysis that is scored from 1 (complete paralysis) to 21 (normal movement), injured and untreated rats scored a 2. Those rats that were treated with the chemical-filled tube scored between 8 and 11, depending on the chemical used.

The tube, made of the same material used for contact lenses and only 5 millimeters in length, fits snugly around the injured area and serves as a bridge that connects the damaged nerves. Designed to mimic the flexibility of the spinal cord, the tube provides a pathway along which neurons can grow.

We saw some directed nerve tissue growth along the plastic tube, but we do not yet know if the severed nerves were connected to the newly grown tissue, said Shoichet. We hope that once axons grow across the gap they will make the appropriate connections.

Unlike nerves in other parts of the body which regenerate rapidly after an injury, spinal cord nerves must be coaxed into growing. Other researchers are testing the practicality of using injections or genetically-modified cells to deliver growth factors to the
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28-Aug-2001


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