HOME >> BIOLOGY >> NEWS
Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

Budding yeast in a UC San Francisco lab are yielding possible insight into a key step leading to the creation of human sperm. And the finding, say the UCSF researchers, could ultimately pave the way for an understanding of why human sperm sometimes doesn't fully develop, causing sterility.

In their study, published in the April issue of Molecular Cell, the UCSF researchers have identified the molecular steps that are involved in pushing a yeast spore, the equivalent of human sperm, through a critical stage of development. And they have determined that when these steps don't take place development is arrested--permanently.

Intriguingly, this finding may offer insight into the molecular glitch that causes a male infertility syndrome. Men with the infertility syndrome have immature sperm that are developmentally interrupted at the same stage of creation as was observed in defective yeast spores.

"This observation sets out a whole paradigm for exploring the human genetics of infertility in men," says Renee Reijo, a leading researcher on sperm-related infertility in men and a UCSF assistant professor of obstetrics-gynecology and reproductive sciences. "It is probably the most elegant model for examining the creation of sperm I've seen."

"If nothing else," says lead author Shelley Chu, a graduate student in the laboratory of Ira Herskowitz, PhD, professor of biochemistry and biophysics, and co-director of the Program in Human Genetics at UCSF, "this study provides a framework for understanding how sperm progress through this critical stage of development. Until now, we didn't have a clue about the molecular targets responsible for this transition." Chu is in the UCSF Program of Genetics and Cell Biology.

While yeast, single-celled fungi, are best known for their role in making beer brew and bread rise, their sp
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
23-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Budding viral hijackers may co-opt cell machinery for the getaway
2. Yeast mutations offer window into human disease
3. Yeast model yields insights into Parkinsons disease
4. Yeast helps researchers better understand Parkinsons mystery
5. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
6. Yeast genomes reveal new sites of gene control
7. Yeast research targets drug resistance battle
8. Yeast underscores complexity of genetic variation between people
9. Yeast Provides Evidence For Continuous Membrane Theory
10. Yeast Rises To A New Occasion
11. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back ... 8th June 2018 in San Francisco, CA. The Summit brings together current and former ... CEOs, board directors and government officials from around the world to address key issues ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: