HOME >> BIOLOGY >> NEWS
Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

ores, which carry the genes leading to offspring, have a lot in common with sperm.

Both spore and sperm are created from other cells only after undergoing a complex process known as meiosis, in which a cell's DNA replicates and then undergoes two steps of division. Spore and sperm also have unique shapes relative to the cells that created them. In addition, two matured yeast spores can fuse to produce progeny just as sperm and egg fuse to produce offspring.

Spore and sperm are also both susceptible to being blocked in mid development, just before the cells from which they are produced undergo the first of the two divisions of their DNA. This interruption occurs at a stage of meiosis called pachytene and, in most cases, is temporary and beneficial, serving as a period during which the cell can repair any damage that may have occurred up to that point in development.

At least in human sperm, however, interruption can be permanent, preventing the further development of the cell--and thereby causing sterility, as in testicular maturation arrest.

In the UCSF study, the researchers determined that a gene, known as NDT80, plays a critical role in this pachytene stage of meiosis in yeast. They found that the NDT80 gene encodes the critical protein that acts to stimulate the synthesis of a set of proteins known as cyclins, which spark entry into DNA division. They also determined that the Ndt80 protein is responsible for the synthesis of another set of proteins, which contribute to the unique shape of the spore.

Finally, the authors showed that Ndt80 is itself controlled by a so-called "check point" protein called Rad17. Normally, check point proteins play the invaluable role of stalling further cell development when there are indications of damage, until repair has taken place. If a precursor cell's DNA has somehow accum
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
23-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Budding viral hijackers may co-opt cell machinery for the getaway
2. Yeast mutations offer window into human disease
3. Yeast model yields insights into Parkinsons disease
4. Yeast helps researchers better understand Parkinsons mystery
5. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
6. Yeast genomes reveal new sites of gene control
7. Yeast research targets drug resistance battle
8. Yeast underscores complexity of genetic variation between people
9. Yeast Provides Evidence For Continuous Membrane Theory
10. Yeast Rises To A New Occasion
11. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs

Post Your Comments:
(Date:11/18/2014)... BOSTON , Nov. 17, 2014   ... HealthCare and EMC collaborate to develop The Partners ... , The Partners Data Lake will allow ... to improve diagnostics, treatment and the lives of ... support research and clinical activities across the Partners ...
(Date:11/11/2014)...  Forensicon, Inc., a Chicago -based ... the promotion of Yaniv Schiff from Senior ... Schiff,s new role as Director, he will lead company ... examiners and provide leadership within the company,s digital forensics ... Schiff joined Forensicon in 2006 ...
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2
(Date:11/21/2014)... The science of light and how ... more than 200 primary students in a traveling program ... of Otago Physics Department and funded by an ... of the university’s OSA/SPIE Student Chapter visited six primary ... children from small, rural schools hands-on lessons in optics ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... 2014 Polaris Group announced today that ... Phase 1 trial of ADI-PEG 20 in combination ... malignant pleural mesothelioma (MPM) and non-squamous non-small cell ... on ADI-PEG 20, both as monotherapy and in ... several other indications, including breast cancer, melanomas, ovarian ...
(Date:11/18/2014)... RPS Diagnostics (RPS®) – a ... announces its third annual partnership of the Centers ... About Antibiotics Week from November 17-23. , Get ... designed to highlight the coordinated efforts of CDC, ... for-profit partners to provide education about the importance ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
Cached News: