HOME >> BIOLOGY >> NEWS
Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

ores, which carry the genes leading to offspring, have a lot in common with sperm.

Both spore and sperm are created from other cells only after undergoing a complex process known as meiosis, in which a cell's DNA replicates and then undergoes two steps of division. Spore and sperm also have unique shapes relative to the cells that created them. In addition, two matured yeast spores can fuse to produce progeny just as sperm and egg fuse to produce offspring.

Spore and sperm are also both susceptible to being blocked in mid development, just before the cells from which they are produced undergo the first of the two divisions of their DNA. This interruption occurs at a stage of meiosis called pachytene and, in most cases, is temporary and beneficial, serving as a period during which the cell can repair any damage that may have occurred up to that point in development.

At least in human sperm, however, interruption can be permanent, preventing the further development of the cell--and thereby causing sterility, as in testicular maturation arrest.

In the UCSF study, the researchers determined that a gene, known as NDT80, plays a critical role in this pachytene stage of meiosis in yeast. They found that the NDT80 gene encodes the critical protein that acts to stimulate the synthesis of a set of proteins known as cyclins, which spark entry into DNA division. They also determined that the Ndt80 protein is responsible for the synthesis of another set of proteins, which contribute to the unique shape of the spore.

Finally, the authors showed that Ndt80 is itself controlled by a so-called "check point" protein called Rad17. Normally, check point proteins play the invaluable role of stalling further cell development when there are indications of damage, until repair has taken place. If a precursor cell's DNA has somehow accum
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
23-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Budding viral hijackers may co-opt cell machinery for the getaway
2. Yeast mutations offer window into human disease
3. Yeast model yields insights into Parkinsons disease
4. Yeast helps researchers better understand Parkinsons mystery
5. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
6. Yeast genomes reveal new sites of gene control
7. Yeast research targets drug resistance battle
8. Yeast underscores complexity of genetic variation between people
9. Yeast Provides Evidence For Continuous Membrane Theory
10. Yeast Rises To A New Occasion
11. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com , ... published the overview results from the Q1 wave of ... recent wave was consumers, receptivity to a program where ... with a health insurance company. "We were ... share," says Michael LaColla , CEO of Troubadour ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology:
Cached News: