HOME >> BIOLOGY >> NEWS
Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

ulated damage during meiosis, for instance, Rad17 will hold off on prompting Ndt80 until the problem has been repaired. Once the damage has been fixed, Rad17 will then allow Ndt80 to act, and the cell will continue through the process of spore creation.

The question interesting the UCSF researchers is whether there is a molecular pathway in the creation of human sperm that is similar to the one they have observed in yeast. And, if so, whether a human equivalent to Ndt80 or Rad17 might be involved in progression through the pachytene stage of sperm development.

Other research groups have reported a burst in cyclin synthesis at the pachytene stage of meiosis in both fly and mouse that resembles the actions of Ndt80. This suggests, say the UCSF researchers, that an equivalent gene may have been conserved throughout evolution.

Moreover, there is some question as to whether NDT80 may parallel, in some aspects, a set of genes known as DAZ, which are found on the human Y, or male, chromosome. Both the NDT80 gene in yeast, and DAZ genes in men, are required for development beyond the pachytene stage in spore and sperm, respectively.

Previous research conducted by UCSF's human male infertility researcher Reijo and co-workers showed that the DAZ genes are deleted in 13 percent of infertile men, and in many of these men sperm development is permanently arrested--again, at the pachytene stage of meiosis.

"There are probably hundreds of yet to be discovered genes involved in the creation of human sperm," says Reijo, "and we're not saying DAZ and NDT80 are the same genes or that DAZ is regulated by the equivalent of Rad17, but since there's pachytene arrest in both, we may be on to something." "Their work makes me even more curious about what is regulating DAZ," says Reijo. "I think now we can put together the spermatogenesis
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
23-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Budding viral hijackers may co-opt cell machinery for the getaway
2. Yeast mutations offer window into human disease
3. Yeast model yields insights into Parkinsons disease
4. Yeast helps researchers better understand Parkinsons mystery
5. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
6. Yeast genomes reveal new sites of gene control
7. Yeast research targets drug resistance battle
8. Yeast underscores complexity of genetic variation between people
9. Yeast Provides Evidence For Continuous Membrane Theory
10. Yeast Rises To A New Occasion
11. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... WAXHAW, N.C. (PRWEB) , ... August 20, 2019 ... ... the organic development and commercialization of bioactive technologies for the spine, today announced ... The EVOL-SI features a unique surface modification that is proven to improve osseointegration ...
(Date:8/15/2019)... ... August 15, 2019 , ... ... relieve lab staff of routine tasks. That was the message at the world's ... researcher Kalorama Information. The American Association for Clinical Chemistry (AACC) Annual Scientific Meeting ...
(Date:8/14/2019)... ... August 14, 2019 , ... Gateway Genomics , a ... announces inclusion in the 38th annual Inc. 500|5000 list of fastest growing ... qualify, companies must have been founded and generating revenue by March 31, 2015. Ranking ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today ... (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene expression ... also increased the cells’ ability to lodge into bone marrow. This research performed ...
(Date:5/31/2019)... ... 29, 2019 , ... For many years, the primary forms of cancer treatment ... therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T ... cell receptors known as “CARs”. The CAR enables the final product to produce chemicals ...
(Date:5/31/2019)... ... 2019 , ... World Compliance Seminars today announced a live ... Boston, MA. This peer recommended interactive workshop is always selected by professionals at ... off with a compendial treatment of Data Integrity fundamentals. After laying the groundwork, ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... demonstrate an efficient delivery system for the sustained release of human placental stem ... gel system was able to deliver CM into the injured kidney, where it ...
Breaking Biology Technology:
Cached News: