HOME >> BIOLOGY >> NEWS
Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

ulated damage during meiosis, for instance, Rad17 will hold off on prompting Ndt80 until the problem has been repaired. Once the damage has been fixed, Rad17 will then allow Ndt80 to act, and the cell will continue through the process of spore creation.

The question interesting the UCSF researchers is whether there is a molecular pathway in the creation of human sperm that is similar to the one they have observed in yeast. And, if so, whether a human equivalent to Ndt80 or Rad17 might be involved in progression through the pachytene stage of sperm development.

Other research groups have reported a burst in cyclin synthesis at the pachytene stage of meiosis in both fly and mouse that resembles the actions of Ndt80. This suggests, say the UCSF researchers, that an equivalent gene may have been conserved throughout evolution.

Moreover, there is some question as to whether NDT80 may parallel, in some aspects, a set of genes known as DAZ, which are found on the human Y, or male, chromosome. Both the NDT80 gene in yeast, and DAZ genes in men, are required for development beyond the pachytene stage in spore and sperm, respectively.

Previous research conducted by UCSF's human male infertility researcher Reijo and co-workers showed that the DAZ genes are deleted in 13 percent of infertile men, and in many of these men sperm development is permanently arrested--again, at the pachytene stage of meiosis.

"There are probably hundreds of yet to be discovered genes involved in the creation of human sperm," says Reijo, "and we're not saying DAZ and NDT80 are the same genes or that DAZ is regulated by the equivalent of Rad17, but since there's pachytene arrest in both, we may be on to something." "Their work makes me even more curious about what is regulating DAZ," says Reijo. "I think now we can put together the spermatogenesis
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
23-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Budding viral hijackers may co-opt cell machinery for the getaway
2. Yeast mutations offer window into human disease
3. Yeast model yields insights into Parkinsons disease
4. Yeast helps researchers better understand Parkinsons mystery
5. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
6. Yeast genomes reveal new sites of gene control
7. Yeast research targets drug resistance battle
8. Yeast underscores complexity of genetic variation between people
9. Yeast Provides Evidence For Continuous Membrane Theory
10. Yeast Rises To A New Occasion
11. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... (PRWEB) , ... May 01, 2020 , ... More than ... Comprehensive Cancer Center’s High-Risk Cancer Program, which is led by two genetic counselors. , ... solutions, today announced it is teaming up with UConn’s High Rick Program to ensure ...
(Date:4/26/2020)... ... April 23, 2020 , ... SECO , ... FII Tech Growth managed by Fondo Italiano d’Investimento SGR, today announced a partnership ... development of Respira, a new non-invasive pulmonary ventilator created in response to the ...
(Date:4/22/2020)... ... April 21, 2020 , ... USDM Life Sciences ... compliance, announces a new managed service to improve quality management for regulated companies, ... and USDM Life Sciences (USDM) – Unify Compliance Cloud is a suite of ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... May 19, 2020 , ... Eaton Square is pleased to announce its ... Company, a biotechnology and medical technology-focused strategy and M&A advisory firm. , This is ... States, linking US and Asia Pacific healthcare innovators with capital and investors. , Popper ...
(Date:5/15/2020)... (PRWEB) , ... May 14, 2020 , ... This new ... unforeseen and the most pressing questions answered quickly as the need arises. Lachman’s OnCall ... offering valuable advice at affordable rates. , Lachman OnCall™ SMEs are available normal ...
(Date:5/14/2020)... ... 13, 2020 , ... In collaboration with Sartorius, Biocompare has ... Life Science Lab . The comprehensive information source was created for life scientists ... handling to contamination control. , The content hub features the latest guidance about ...
(Date:5/5/2020)... ... ... ProductLife Group has marked the next phase in its global ... years at Altran, where he was Group VP of Life Sciences and Head of ... Xavier was involved in his early career in the development of new medical devices ...
Breaking Biology Technology:
Cached News: