HOME >> BIOLOGY >> NEWS
Possible Trigger For Heart Failure Identified In Lab Animal Studies

DALLAS, April 14 -- Researchers have demonstrated in laboratory animals that tumor necrosis factor alpha, a protein produced in the heart, can lead to congestive heart failure. The finding may pave the way for a new treatment for the nation's fastest-growing heart disease. The studies, from two different research teams, appear in today's Circulation: Journal of the American Heart Association.

Released by the body to help heal injured tissue, tumor necrosis factor alpha (TNF), can initiate an "inflammatory cascade," or immune reaction, that may turn against the heart and weaken it, resulting in congestive heart failure, according to scientists at the University of Texas Southwestern Medical Center in Dallas and Baylor College of Medicine in Houston. One study also found that TNF is produced not just by white blood cells, but also by heart muscle cells called myocytes.

The Dallas scientists demonstrated that laboratory mice who were genetically altered so their heart cells produced an excess of TNF pumped less blood and developed an enlarged heart -- the primary features of congestive heart failure in humans.

Afflicting almost 5 million Americans, congestive heart failure is the single most frequent cause of hospitalizations for people age 65 or older, according to the American Heart Association. From 1979 to 1995, deaths from heart failure increased 115.7 percent.

In the study, researchers developed two lines of transgenic mice which expressed TNF in the heart. The two lines, which included 30 mice, died prematurely of heart failure. The progression of heart failure was directly related to the amount of TNF. Mice which did not express TNF in the heart proved to be free of disease, notes Deborah Bryant, B.S., the study's lead author. She is a senior research associate at U.T. Southwestern's department of pediatrics.

"Production of TNF by cardiac myocytes is sufficient to cause myocardit
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
13-Apr-1998


Page: 1 2 3

Related biology news :

1. Possible new cure for psoriasis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Possible mechanism for link between diabetes and Alzheimers disease discovered
4. Scientists switch components in cell circuits: Possible new technology, therapy
5. Possible new cell type found in developing inner ear
6. Possible gene for form of mental retardation, brain development identified
7. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
8. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
9. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
10. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
11. Mechanism For Fungal Adherence Found, Possible Key To Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com , ... published the overview results from the Q1 wave of ... recent wave was consumers, receptivity to a program where ... with a health insurance company. "We were ... share," says Michael LaColla , CEO of Troubadour ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology:
Cached News: