HOME >> BIOLOGY >> NEWS
Possible cause and treatment for shock uncovered by UC San Diego bioengineers

Researchers prevented shock and multiple organ failure in experimental animals by blocking powerful pancreatic digestive enzymes in the intestine, according to studies by bioengineers with the Jacobs School of Engineering at the University of California, San Diego. This fundamental breakthrough could lead to therapies to prevent and treat ischemic shock in people who experience shock following blood loss from traumatic injury or high-risk surgery. The work also provides clues into the cellular mechanisms that lead to shock.

The research report titled "Generation of In Vivo Activating Factors in the Ischemic Intestine by Pancreatic Enzymes" will be published in the Proceedings of the National Academy of Sciences on February 15. The principal investigator of the study is Geert Schmid-Schoenbein, professor of bioengineering at the Jacobs School of Engineering, and the work was funded by the National Heart, Lung, and Blood Institute. The research was conducted with Hiroshi Mitsuoka and Erik Kistler in Schmid-Schoenbein's Microcirculation Research Laboratory.

Ischemic shock occurs when blood pressure falls after blood loss or deep anesthesia. Vital organs are poorly perfused and literally starved of oxygen. Early symptoms include cold, clammy skin, mental confusion and inadequate production of urine. But shock can quickly lead to multiple organ failure and even death.

These symptoms are induced when activators in the blood stream turn on various cardiovascular cells including leukocytes (white blood cells) and endothelial cells (blood vessel walls). Abnormal interactions between leukocytes and endothelial cells produce inflammation, alter blood flow, and finally cut off delivery of oxygen to the organs.

But never before have researchers found strong evidence for the source of the cell activators. "The pancreas produces potent enzymes that can dige
'"/>

Contact: Denine Hagen
dhagen@ucsd.edu
858-534-2920
University of California - San Diego
13-Feb-2000


Page: 1 2

Related biology news :

1. Possible new cure for psoriasis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Possible mechanism for link between diabetes and Alzheimers disease discovered
4. Scientists switch components in cell circuits: Possible new technology, therapy
5. Possible new cell type found in developing inner ear
6. Possible gene for form of mental retardation, brain development identified
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Mechanism For Fungal Adherence Found, Possible Key To Disease
11. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 21, 2020 , ... ... technology-based services specializing in background and medical screening, announces the launch of ... and keeping their workforce safe. The new service is provided by ClearStar’s ...
(Date:5/21/2020)... ... May 20, 2020 , ... ... solutions for drugs, biologics, cell and gene therapies, and consumer health products, today ... Therapy, will be presenting at the ISCT 2020 Paris Virtual conference, which takes ...
(Date:5/21/2020)... ... 21, 2020 , ... Agility Orthopedics, home to dedicated specialists ... is pleased to announce a partnership with Dallas-based Simple Interact to further enhance ... area, Agility Orthopedics is focused on speeding up patient workflows to enhance patient ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... ... multiple open heart surgeries before becoming adults. The reason: there are ... address this critical unmet need, the Department of Defense has awarded Draper, Boston ...
(Date:5/14/2020)... ... 2020 , ... DuPont Nutrition & Biosciences (N&B) has announced ... care ingredients in Russia and Belarus. Beginning May 1, Interdisp JCS will represent ... , The GENENCARE®OSMS product line contains a range of all-natural, 100 ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages of drug discovery ... no information on the drug’s mechanism of action (MOA). Gene expression profiling technologies ... the activity of molecular pathways. This information can complement phenotypic readouts and can ...
(Date:5/5/2020)... ... May 05, 2020 , ... ProductLife Group has ... Xavier Duburcq joins the group after 13 years at Altran, where he was Group ... PhD in Immunology and being a Pharmacist, Xavier was involved in his early career ...
Breaking Biology Technology:
Cached News: