HOME >> BIOLOGY >> NEWS
Possible cause and treatment for shock uncovered by UC San Diego bioengineers

Researchers prevented shock and multiple organ failure in experimental animals by blocking powerful pancreatic digestive enzymes in the intestine, according to studies by bioengineers with the Jacobs School of Engineering at the University of California, San Diego. This fundamental breakthrough could lead to therapies to prevent and treat ischemic shock in people who experience shock following blood loss from traumatic injury or high-risk surgery. The work also provides clues into the cellular mechanisms that lead to shock.

The research report titled "Generation of In Vivo Activating Factors in the Ischemic Intestine by Pancreatic Enzymes" will be published in the Proceedings of the National Academy of Sciences on February 15. The principal investigator of the study is Geert Schmid-Schoenbein, professor of bioengineering at the Jacobs School of Engineering, and the work was funded by the National Heart, Lung, and Blood Institute. The research was conducted with Hiroshi Mitsuoka and Erik Kistler in Schmid-Schoenbein's Microcirculation Research Laboratory.

Ischemic shock occurs when blood pressure falls after blood loss or deep anesthesia. Vital organs are poorly perfused and literally starved of oxygen. Early symptoms include cold, clammy skin, mental confusion and inadequate production of urine. But shock can quickly lead to multiple organ failure and even death.

These symptoms are induced when activators in the blood stream turn on various cardiovascular cells including leukocytes (white blood cells) and endothelial cells (blood vessel walls). Abnormal interactions between leukocytes and endothelial cells produce inflammation, alter blood flow, and finally cut off delivery of oxygen to the organs.

But never before have researchers found strong evidence for the source of the cell activators. "The pancreas produces potent enzymes that can dige
'"/>

Contact: Denine Hagen
dhagen@ucsd.edu
858-534-2920
University of California - San Diego
13-Feb-2000


Page: 1 2

Related biology news :

1. Possible new cure for psoriasis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Possible mechanism for link between diabetes and Alzheimers disease discovered
4. Scientists switch components in cell circuits: Possible new technology, therapy
5. Possible new cell type found in developing inner ear
6. Possible gene for form of mental retardation, brain development identified
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Mechanism For Fungal Adherence Found, Possible Key To Disease
11. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... Calif. , Nov. 17, 2016  AIC announces that it has just released ... in organizations that require high-performance scale-out plus high speed data transfer storage solutions. ... ... ... Setting up a high ...
(Date:11/14/2016)... -- xG Technology, Inc. ("xG" or the "Company") (Nasdaq: XGTI, ... use in challenging operating environments, announced its results for ... hold a conference call to discuss these results on ... below). Key Recent Accomplishments ... to acquire Vislink Communication Systems. The purchase is expected ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... 2016 According to the ... Products (Consumable, Instruments, Automated Cell Expansion System), Cells ... Cell Research, Cancer, and Cell-Based Research), End-users (Biopharmaceutical ... Global Revenue, Trends, Growth, Share, Size and Forecast ... global cell expansion market is expected to reach ...
(Date:12/5/2016)... MDx announced today that it brought its NxGen Informed Prenatal Test in-house. ... improve customer service through shortened turnaround times and at the same time ... NxGen MDx. ... A decrease in turnaround times by 25% combined with ... the Grand Rapid headquarters. The NxGen Informed Prenatal Test uses ...
(Date:12/5/2016)... 2016 The U.S. Biotechnology industry ... billion of revenue and some $890 billion of total ... global biopharmaceuticals, and this figure is expected to exceed ... up these four equities for assessment: Northwest Biotherapeutics Inc. ... ACAD ), Acorda Therapeutics Inc. (NASDAQ: ...
(Date:12/4/2016)...  In five studies being presented today during the ... Exposition in San Diego , researchers ... delivery of life-saving treatments to patients with a variety ... carry therapies directly to the sites in the body ... substantial advantage over traditional, systemic methods. The studies highlight ...
Breaking Biology Technology:
Cached News: