HOME >> BIOLOGY >> NEWS
Possible gene for form of mental retardation, brain development identified

Researchers funded by the National Institute of Child Health and Human Development (NICHD) have come one step closer to identifying one of the causes of previously unexplained mental retardation. The researchers report finding a single gene on the X chromosome, called AGTR2 for short, that when abnormal, appears to result in mental retardation (MR). The study, by Dr. Anand K. Srivastava and colleagues of the J.C. Self Research Institute of Human Genetics at the Greenwood Genetic Center in South Carolina, is published in the June 28 issue of Science.

"The identification of a single gene mutation that may prove to be the cause of some cases of mental retardation is very encouraging," said Duane Alexander, M.D., Director of the NICHD. "This advance not only may lead to insights into a variety of new therapies, but may also help us to better understand the processes involved in normal brain development."

Like an instruction manual, a gene contains information that tells the body how to make one or more specific proteins. A protein, in turn, performs a specific activity or group of activities within the body's cells. When a gene is mutated, or altered, however, it will produce an altered protein or will not produce a protein at all. Often, a gene mutation does not noticeably affect the body. Other gene mutations, however, can result in disease or disrupt normal development.

The researchers linked a mutation in the AGTR2 (Angiotensin II receptor 2) gene to mental retardation by studying a female patient with unexplained MR. The researchers knew that this patient had a chromosome translocation between one of the X chromosomes and one of the number 7 chromosomes, meaning that during development, two of her chromosomes broke, and then switched pieces. They suspected that this translocation resulted in a mutation in one of the genes on the broken X chromosome and that the mutation could have resulted in the patient's developmental disabilities. To t
'"/>

Contact: Susan Marsiglia and Robert Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
27-Jun-2002


Page: 1 2

Related biology news :

1. Possible new cure for psoriasis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Possible mechanism for link between diabetes and Alzheimers disease discovered
4. Scientists switch components in cell circuits: Possible new technology, therapy
5. Possible new cell type found in developing inner ear
6. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Mechanism For Fungal Adherence Found, Possible Key To Disease
11. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a ... intravenous (IV) therapy, today announced receipt of its ISO 13485 Certification, ... by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early ... "This is an ...
(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past two ... with crowdsourced data collection, GeneFo now offers this platform to healthcare ... and amplifying support, adherence, and data collection vis a vis their ... mark the successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/14/2017)... Portland, Oregon (PRWEB) , ... August 14, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... hardware. , SYZYGY is intended to satisfy the need for a compact, low ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... and, in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President ... Wave, with the established manufacturing presence and know-how of Biorigin will allow us ...
Breaking Biology Technology:
Cached News: