HOME >> BIOLOGY >> NEWS
Possible link discovered between gene responsible for blood vessel development and ACD in newborns

TORONTO Researchers at St. Michael's Hospital examining a gene responsible for blood vessel development have discovered a possible link to a fatal respiratory disease in newborns which has no identified cause or cure. The study appears on-line today in Circulation Research, a journal published by the American Heart Association.

Results of the study, which examined mice lacking Endothelial NO Synthase (eNOS), a gene important in blood vessel growth, show that offspring of these animals had major defects in their lung development which resulted in respiratory distress and death.

"We found that the lungs of eNOS deficient mice share the same features as newborns with a fatal condition known as Alevolar Capillary Dysplasia (ACD)," says Dr. Duncan Stewart, Chief of Cardiology, and Associate Director, Basic Science Research, St. Michael's Hospital and the Dexter Man Chair of Cardiology, University of Toronto. "This discovery opens up a door into the possible cause of ACD. Knowing that there is a defect in vessel formation in the lung, we can examine potential therapies for ACD, including using techniques previously used for heart disease such as stem cells and gene therapy to stimulate the growth of blood vessels in the lung."

Infants born with ACD, a rare disease with no known cause or cure, develop respiratory distress and quickly become critically ill. The condition is always fatal. The small blood vessels and capillaries in the lungs are not properly formed and the lungs typically show a misalignment of the pulmonary veins.

At St. Michael's Hospital, Dr. Stewart and Robin Han, Research Associate, studied genetically engineered mice lacking the eNOS gene to determine the cause of neonatal death in the mutant animals' offspring. They discovered that this deficiency caused major defects in the lung, resulting in respiratory distress and death. Tests showed that small blood vessels and capillaries were not formed properly and there was
'"/>

Contact: Tracy MacIsaac
416-864-5047
University of Toronto
11-Mar-2004


Page: 1 2

Related biology news :

1. Possible new cure for psoriasis
2. Possible mechanism for link between diabetes and Alzheimers disease discovered
3. Scientists switch components in cell circuits: Possible new technology, therapy
4. Possible new cell type found in developing inner ear
5. Possible gene for form of mental retardation, brain development identified
6. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Mechanism For Fungal Adherence Found, Possible Key To Disease
11. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... ALLENTOWN, Pa. , March 20, 2017 ... PD 2.0 personal spirometer and Wellness Management System (WMS), ... Founded in 2010, PMD Healthcare is a ... Company with a mission dedicated to creating innovative solutions ... of life. With that intent focus, PMD developed the ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 /PRNewswire/ ... 23andMe , the leading personal genetics company, are ... can now provide customers with personalized nutrition plans that ... biometrics, but also genetic markers impacting how their body ... personalized food decision support platform uses biometrics such as ...
(Date:3/2/2017)... -- Summary This report provides all the information ... and activities since 2010. ... Read the full report: http://www.reportlinker.com/p03605615-summary/view-report.html ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... , March 22, 2017 Oramed Pharmaceuticals ... www.oramed.com ), a clinical-stage ... drug delivery systems, announced today that Dr. ... deliver a presentation titled, "Oral Insulin for Diabetes ... Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics (OPT) Boston Conference ...
(Date:3/22/2017)... ALBANY, New York , March 22, 2017 /PRNewswire/ ... market is largely fragmented, states a research report by ... Sanofi S.A., Pfizer Inc., Amgen Inc., and AbbVie Inc., ... market in 2015. The prominent players in this market ... to expand their product portfolio, which is likely to ...
(Date:3/22/2017)... , March 22, 2017 /PRNewswire/ - FACIT announced ... "Company" or "Propellon"), a start-up created by FACIT ... therapeutics. FACIT,s investment, combined with non-dilutive capital, achieves ... The seed funding enables Propellon to accelerate the ... Company for financing and/or entering a strategic partnership ...
(Date:3/22/2017)... 2017   VWR (NASDAQ: VWR), ... and service solutions to laboratory and production ... EPL Archives, Inc., an international biorepository services ... regulated product research, development and commercialization lifecycle ... ancillary services. EPL Archives is widely recognized ...
Breaking Biology Technology:
Cached News: