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Possible link discovered between gene responsible for blood vessel development and ACD in newborns

a misalignment of pulmonary veins, features that are shared by newborns with ACD.

"We know from past research that eNOS is required for angiogenic genes to produce new blood vessels in the heart and elsewhere," says Dr. Stewart. Results of this study show that eNOS also plays a previously unrecognized role in lung development. "This is an exciting discovery as it is the first insight into the genetic basis of this human condition which is always fatal."

St. Michael's Hospital worked with researchers at The Hospital for Sick Children on the link between the deficient gene and ACD. "The aim of our research program is to understand the cellular and molecular physiological mechanisms that direct lung development with the long term objective to use the information to develop new therapeutic strategies or to improve existing therapies," says Dr. Martin Post, Head of the Lung Biology program and Interim Head of the Integrative biology program at The Hospital for Sick Children (Sick Kids) Research Institute, a Professor of Paediatrics in the Departments of Physiology, Laboratory Medicine and Pathology at the University of Toronto and a Canada Research Chair in Fetal, Neonatal & Maternal Health.


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Contact: Tracy MacIsaac
416-864-5047
University of Toronto
11-Mar-2004


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