HOME >> BIOLOGY >> NEWS
Possible mechanism for link between diabetes and Alzheimer's disease discovered

Boston, MA For some time, researchers have known that people with diabetes have a greater risk of developing Alzheimer's disease and other forms of dementia than those without diabetes, but the exact cause of this link has not been known. Now, a new study by researchers in Cologne, Germany, and at Joslin Diabetes Center in Boston, to be published this week online in the Proceedings of the National Academy of Sciences, suggests that insulin resistance in brain cells can affect how they function, causing some of the biochemical changes typically seen in Alzheimer's disease.

Insulin resistance is a major contributor to type 2 diabetes, obesity and the metabolic syndrome, which affect nearly one-quarter of the American population. In these insulin resistant states, tissues of the body such as muscle, liver, and fat fail to respond normally to the insulin produced by the pancreas, leading to a wide range of metabolic abnormalities. In patients with diabetes, this includes elevated blood sugar levels which, if uncontrolled, can lead to such vascular complications as blindness, limb amputations, kidney disease, heart disease, stroke and nerve damage.

Through research at Joslin Diabetes Center and elsewhere, scientists only recently have come to realize that insulin receptors are present on all tissues of the body, including the brain, and may affect the function of these tissues. Furthermore, various research findings have suggested that disruption of the insulin signaling system may occur in such disorders as Alzheimer's disease and Parkinson's disease. In fact, at least one large European study found people with diabetes to be at least twice as likely to develop Alzheimer's disease as someone without the disease. The risk was even higher among those people with diabetes taking insulin.

To study the effects of insulin resistance in the brain, Jens C. Bruning, M.D., formerly of Joslin Diabetes Center and now of the University of Cologne, Germany
'"/>

Contact: Marge Dwyer
marjorie.dwyer@joslin.harvard.edu
617-732-2415
Joslin Diabetes Center
16-Feb-2004


Page: 1 2

Related biology news :

1. Possible new cure for psoriasis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Scientists switch components in cell circuits: Possible new technology, therapy
4. Possible new cell type found in developing inner ear
5. Possible gene for form of mental retardation, brain development identified
6. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UV Rays, Fire And Flame Retardants To Be Reviewed For Possible Listing As Carcinogens, NTP Announces
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Mechanism For Fungal Adherence Found, Possible Key To Disease
11. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... 2017  GCE Solutions, a global clinical research organization (CRO), announces ... solution on October 4, 2017. Shadow is designed to assist medical ... policy 0070 of the European Medicines Agency (EMA) in meeting the ... ... ...
(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ... board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to ... Delta,s biometric ... Sky Club is now integrated into the boarding process to allow ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
(Date:10/10/2017)... ... 10, 2017 , ... Dr. Bob Harman, founder and CEO of VetStem ... The event entitled “Stem Cells and Their Regenerative Powers,” was held ... Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences ... the life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and ... presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
Breaking Biology Technology:
Cached News: