HOME >> BIOLOGY >> NEWS
Potential cause of arthritis discovered

Reporter's Note: A news conference on this research will be held Wednesday, Aug. 21, 12:00 noon, at the Hynes Convention Center, Room 301, in Boston, Mass.

BOSTON Researchers at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS) have shown that certain types of naturally occurring carbohydrates in the body may cause rheumatoid arthritis, a debilitating, painful disease affecting hundreds of millions of people worldwide.

Although there have been promising advances in treating the symptoms of arthritis, the exact causes of arthritic inflammation, swelling, and destruction of the joints has remained elusive. Now, researchers at BWH have for the first time associated carbohydrates present naturally in the body with this disease.

Dr. Julia Ying Wang, the lead BWH researcher in the study, and an Assistant Professor of Medicine at HMS, has extensively examined the role of carbohydrates in diseases and infections. She will present her recent findings on arthritis at the American Chemical Society's national meeting, to be held from August 18th through August 22nd, at the Hynes Convention Center and surrounding hotels.

Wang began wondering whether a particular class of carbohydrates, known as glycosaminoglycans (GAGs), triggered an immune response in the body. GAGs are naturally present as a major component of joint cartilage, joint fluid, connective tissue, and skin. In collaboration with Michael H. Roehrl, M.D., from HMS, Wang studied the effects GAGs had on mice, who subsequently experienced arthritic symptoms, including swelling, inflammation, and joint damage.

"This study shows that rheumatoid arthritis may result from the body's mishandling of its own carbohydrates that, under normal circumstances, would not be interpreted as a threat," said Wang. "We found that inflammatory cells that accumulate in arthritic joints attach themselves directly to the glycosaminoglycans. This accumulation of cells leads
'"/>


21-Aug-2002


Page: 1 2

Related biology news :

1. Potential for enhanced sequestration of carbon in soils supports evaluations
2. Potential blood test for colon cancer risk
3. Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
4. Potential of regenerative medicine explored
5. Potential therapy reported for children, adults with end-stage liver disease
6. Potential allergy vaccine boosts hope for sufferers
7. Potential of tailoring drugs to genetic makeup confirmed--but challenges remain
8. Potential new anthrax therapy discovered
9. Potential gene therapy carriers created that mimic viruses, without the risk
10. New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses
11. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. While the ... economic downturn will only increase price pressures overall for the industry. The era of ... every product launch is critical. However, history shows that only a third of product ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), ... multiple awards for not only the products and treatments developed, but also the ... Microneedle RF. All the brands built by ABM have received several honors already ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® ... in 16 countries, has reached its 20th anniversary of worldwide use. Introduced in ... at top universities including University of Pennsylvania, University of Michigan, University of Maryland, ...
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
Breaking Biology Technology:
Cached News: