Potential new anthrax therapy discovered

Findings could lead to novel treatments against other bacterial infections

Boston, MAA study by Harvard Medical School researchers in the April 27 Science suggests a mutation in the anthrax toxin, which prevents poisoning, may lead to a double-pronged pharmaceutical that is equally effective as a vaccine and as a faster-acting and more broadly protective therapy than currently available.

Death from anthrax is due to the toxin produced by the bacteria. In its airborne form, just a teaspoonful of anthrax could wipe out hundreds of people. Though rarely a natural threat to humans, anthrax is especially dangerous as a potential weapon in terrorism and biological warfare.

Though a vaccine exists, most people have no vaccine-induced immunity to anthrax because the rarity of infection makes a mass vaccination program impractical. Yet current therapies demand that any unvaccinated person exposed to the bug receive antibiotic therapy before symptoms occur. Otherwise, the victim with systemic anthrax dies rapidly. The discovery by R. John Collier and colleagues may offer a better way to fight back before or after infection.

The researchers tested whether they could prevent infection using forms of the anthrax bacterium with a mutation in a toxin subunit dubbed "protective antigen." When protective-antigen mutants were injected together with a normally lethal mix of toxin, rats did not develop any symptoms of poisoning. The protective-antigen variants "totally protected the animals, whereas the control animals became moribund within 90 minutes," says Collier, the Maude and Lillian Presley Professor of Microbiology and Molecular Genetics at the Medical School. "Were most encouraged about the experiments in rats. The results are remarkable."

The protective-antigen mutants are good candidates for an anthrax therapy because the normal form of protective antigen in and of itself is already known to be safe in humans: it is the major component

Contact: John Lacey
Harvard Medical School

Page: 1 2 3

Related biology news :

1. Potential for enhanced sequestration of carbon in soils supports evaluations
2. Potential blood test for colon cancer risk
3. Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
4. Potential cause of arthritis discovered
5. Potential of regenerative medicine explored
6. Potential therapy reported for children, adults with end-stage liver disease
7. Potential allergy vaccine boosts hope for sufferers
8. Potential of tailoring drugs to genetic makeup confirmed--but challenges remain
9. Potential gene therapy carriers created that mimic viruses, without the risk
10. New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses
11. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy

Post Your Comments:

(Date:3/2/2020)... ... March 02, 2020 , ... Toronto-based clinical research organization ... opening its newest office location just 5 minutes south of Clarksburg on a farm ... the property, called End of the Rainbow Orchard, and decided it would be a ...
(Date:2/28/2020)... Kan. (PRWEB) , ... February ... ... proudly announces that its patent-pending Rebound PRP™ and Rebound PRF® devices are ... university-validated a new generation of regenerative medical devices, that will provide the ...
(Date:2/26/2020)... ... February 25, 2020 , ... Renowned eye surgical practice led by ... in Texas to offer the FDA-approved, post-surgical, corrective Light Adjustable Lens (LAL) by RxSight™. ... with excellent results. Dell Laser Consultants is also currently involved in the latest LAL ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... February 20, 2020 , ... The natural ... Humans have been increasingly successful in innovating ways to engineer these natural ... and strategies for modern molecular biology (e.g., gene sequencing, writing, and editing; ...
(Date:2/19/2020)... Conn. (PRWEB) , ... February 18, 2020 , ... ... develops tools for characterizing microbiome populations down to the strain level, recently unveiled ... easy-to-use kit designed for efficient and unbiased isolation of high molecular weight (HMW) ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... pleased to announce the successful results from a long-term follow-up clinical study ... Inspan interspinous fixation device (INSPAN LLC). Unlike extension block design, the Inspan ...
(Date:2/5/2020)... ... February 05, 2020 , ... Rare Disease Day® , held the ... Organization for Rare Disorders (NORD), to raise awareness amongst the general public and decision-makers ... Balancing Act’s “Behind The Mystery” rare disease series will be shining the ...
Breaking Biology Technology:
Cached News: