HOME >> BIOLOGY >> NEWS
Potential therapy reported for children, adults with end-stage liver disease

A Johns Hopkins Children's Center scientist reports success in animal studies in preventing a cascade of brain pathology that appears to both cause and signal the final and fatal stages of acute and chronic liver disease in children and adults. The findings ("Hyperammonemic Encepalopathy") appear in the May issue of Medicine.

In the review article, pediatric biochemical geneticist Saul Brusilow, M.D., writes that the chemical methionine sulfoximine (MSO) appears to prevent the brain swelling (encephalopathy) in patients with acute liver failure. It is the swelling, he believes, that causes pressure on the patient's brain, which leads to coma and ultimately death.

MSO is known to prevent the formation of glutamine, a by-product of high ammonia levels in the blood (hyperammonemia). Patients with advanced liver disease develop hyperammonemia as the failing liver can no longer process ammonia, a natural by-product in humans. "Interrupt glutamine formation and the swelling that follows and we might be able to prevent brain damage and death," says Brusilow.

Experimental evidence suggests that glutamine forms in one type of brain cell, the astrocyte. As glutamine accumulates, water also accumulates, causing the astrocyte to swell. It is this swelling, Brusilow theorizes, that puts pressure on the brain in acute liver failure, and interrupts the normal functions of the astrocyte; patients may then lapse into unconsciousness and death. Patients with chronic liver failure demonstrate the consequences of astrocyte swelling by exhibiting behavioral changes rather than brain swelling.

In their animal studies, Brusilow, emeritus professor of Pediatrics at Johns Hopkins, and his colleagues Richard Traystman, Ph.D., and Raymond Koehler, Ph.D., both in the Department of Anesthesiology and Critical Care Medicine, pretreated rats with MSO, then induced hyperammonemia. Compared to rats not pretreated, the test animals showed no swelling in either their a
'"/>

Contact: Wendy Mullins
wmullins@jhmi.edu
410-223-1741
Johns Hopkins Medical Institutions
13-May-2002


Page: 1 2

Related biology news :

1. Potential for enhanced sequestration of carbon in soils supports evaluations
2. Potential blood test for colon cancer risk
3. Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
4. Potential cause of arthritis discovered
5. Potential of regenerative medicine explored
6. Potential allergy vaccine boosts hope for sufferers
7. Potential of tailoring drugs to genetic makeup confirmed--but challenges remain
8. Potential new anthrax therapy discovered
9. Potential gene therapy carriers created that mimic viruses, without the risk
10. New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses
11. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2019)... SASKATOON, Canada (PRWEB) , ... February 12, 2019 ... ... immediately it will begin operating under its new name, KEYLEAF. The company ... more of its own plant-based extracts and ingredients as finished products under the ...
(Date:2/2/2019)... ... January 31, 2019 , ... ... geared toward clinical operations executives and focusing on all facets of clinical trial ... project management, portfolio management, resource management, patient engagement, and more. , “We ...
(Date:1/25/2019)... ... January 24, 2019 , ... ... PhD, Assistant Professor of Microbiology at the Jackson Laboratory (JAX), to its Scientific ... world, Dr. Oh will bring to uBiome expertise in skin microbial interactions and ...
Breaking Biology News(10 mins):
(Date:2/12/2019)... ... February 12, 2019 , ... ... has finalized a deal to extend their use of Medrio, the leading provider ... 2023. The CRO has been a regular Medrio customer for over nine years, ...
(Date:2/2/2019)... ... , ... Signature Matrix and Signature Cord are the culmination ... cell research expert and Amazon best-selling author, Neil Riordan, PA, PhD, and his ... allograft that originates from the same tissue used to manufacture the purified, expanded ...
(Date:1/30/2019)... ... January 29, 2019 , ... ... Lifecycle since 2016. In his position as Director of Sales and Marketing, Mr. ... services supplier across multiple industries the company supports. During this time, Mr. Schieving ...
(Date:1/30/2019)... ... January 30, 2019 , ... The Society for Laboratory ... to discuss best practices for laboratory automation and screening. This year the conference ... year’s conference, Visikol will be at booth #345 and throughout the conference will ...
Breaking Biology Technology:
Cached News: