Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women

bility to invade immune cells. The ribonucleases may target viral RNA, possibly affecting viral replication.

The new study, published in the March 16 issue of The Proceedings of the National Academy of Sciences, caps an intensive five-year search for the powerful anti-AIDS and anti-cancer agent present in a most unusual source-the urine of pregnant women. Researchers had suspected that human chorionic gonadotropin (hCG), a pregnancy hormone produced by the placenta, was the agent because it inhibited HIV-infected immune cells in the laboratory and in small clinical studies shrank Kaposi's sarcoma tumors in AIDS patients. Moreover, AIDS transmission rarely occurs during the first trimester of pregnancy when hCG levels are high. The main function of hCG is to stabilize pregnancy and protect the embryo from rejection by the mother's body.

However proof of hCG's effects wasn't straightforward. Although crude preparations of hCG inhibited the growth of Kaposi's sarcoma cells and HIV-infected cells in the laboratory, Dr. Lee-Huang and many other scientists showed that highly purified extracts of hCG failed to have any affect on these cells. So it wasn't clear whether hCG itself or some other protein in the urine from which it was prepared was responsible. Dr. Lee-Huang's laboratory narrowed the search to a portion of the hormone called the beta subunit; but to her surprise, the culprits turned out to be other proteins that are also present in the urine and stick to the beta subunit.

In the new study, Dr. Lee-Huang and co-workers isolated the beta subunit from commercial preparations of hCG prepared from the urine of pregnant women. Then, using techniques such as electrophoresis, liquid chromatography and amino acid sequencing, they painstakingly separated and purified the proteins present in the subunit and tested each against HIV-infected cells, as well as analyzed their amino acid sequences. The entire process took about two years.


Contact: Marjorie Shaffer
New York University Medical Center and School of Medicine

Page: 1 2 3

Related biology news :

1. Powerful machines are coming in small packages
2. Powerful new method helps reveal genetic basis of cancer
3. Powerful technologies probe innate immunity
4. Team Solves X-ray Structure Of Powerful Enzyme
5. Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents
6. 3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
7. Agent Orange might boost the risk of leukemia, UNC researcher says
8. Nabi reports successful reduction in S. aureus bacteremias at Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
9. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
10. SFU Spin-Off Company To Research Promising Antibacterial Agents
11. Topical Agent Found To Kill Papillomavirus

Post Your Comments:

(Date:9/14/2019)... N.J. (PRWEB) , ... September 12, 2019 , ... ... development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... of the company’s biologics business. Dr. Schaffer has played an integral advisory role ...
(Date:9/11/2019)... ... September 09, 2019 , ... Greenberg Traurig, LLP attorneys Stephen ... will speak at DeviceTalks Minnesota, Sept. 9-10, at the Hyatt Regency, Minneapolis. Greenberg Traurig ... Sciences & Medical Technology Group have been featured speakers at every DeviceTalks conference ...
(Date:9/8/2019)... ... September 06, 2019 , ... ... human mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announces its release of ... and media system designed for product development. RoosterBio continues to simplify MSC ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
(Date:8/6/2019)... Ill. (PRWEB) , ... August 05, 2019 , ... ... that Jason Casarella has been recognized as a distinguished leader by PharmaVOICE magazine, ... featured in an article in the magazine’s July/August special issue. , As the ...
(Date:8/4/2019)... ... 2019 , ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical ... construction on a 30,000 sq. ft. manufacturing facility in the Coyol free zone, ... facility, which is expected to be fully operational by the end of the year, ...
(Date:7/26/2019)... ... July 25, 2019 , ... LeadingBiotech , an exclusive ... announces its Boston BD conference to be held on September 10, ... Boston , the event provides an opportunity for attendees to leverage insight from ...
Breaking Biology Technology:
Cached News: