HOME >> BIOLOGY >> NEWS
Powerful new method helps reveal genetic basis of cancer

Researchers at Cold Spring Harbor Laboratory have developed one of the most sensitive, comprehensive, and robust methods that now exists for profiling the genetic basis of cancer and other diseases. The method detects chromosomal deletions and amplifications (i.e. missing or excess copies of DNA segments), and is useful for a wide variety of biomedical and other applications.

The study, led by Rob Lucito and Michael Wigler, is published in the October issue of the journal Genome Research (advance on-line publication date: September 15). The powerful new gene discovery method described in the study is called ROMA (Representational Oligonucleotide Microarray Analysis).

By using ROMA to compare the DNA of normal cells and breast cancer cells, the researchers have uncovered a striking collection of chromosomal amplifications and deletions that are likely to be involved in some aspect of breast cancer (see http://roma.cshl.org, password available on request). Some of the DNA amplifications and deletions detected in this study correspond to known oncogenes and tumor suppressor genes. However, many of them are likely to reveal new genes and cellular functions involved in breast cancer or cancer in general.

It would be enough that ROMA is capable of providing a comprehensive, genome-wide view of the genetic alterations associated with breast and other cancers. Such information is invaluable for improving the diagnosis and treatment of the disease. But when comparing "normal to normal" instead of "normal to tumor" DNA samples, Lucito and Wigler got a big surprise.

They frequently detected large (100 kb to 1 Mb) chromosomal deletions and duplications in such normal DNA samples. The scientists speculate that such variations or "copy number polymorphisms" among individuals might well underlie many human traits, including heritable predisposition or resistance to disease.

Background Information Relevant to the Development of ROMA


'"/>

Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
15-Sep-2003


Page: 1 2

Related biology news :

1. Powerful machines are coming in small packages
2. Powerful technologies probe innate immunity
3. Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women
4. Team Solves X-ray Structure Of Powerful Enzyme
5. Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents
6. OHSU researchers discover possible method for early detection, prevention of premature birth
7. Japanese researchers develop novel method of introducing transgenes into animals
8. New screening method turns up potential compound for treating anthrax
9. Radiologists provide safe delivery method for gene therapy
10. New method is first to mimic subtle genetic changes
11. New method for determining age of artifacts fills chronological gap for scientists

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2019)... ... May 24, 2019 , ... Zolgensma (Novartis, AveXis), an AAV-delivered gene therapy used ... use in the United States by the Food and Drug Administration today. ... inherited genetic disorders in the United States and the second-ever approved treatment for SMA. ...
(Date:5/23/2019)... ... 2019 , ... Catalent (Booth 3101), the leading global provider ... products, is to launch its new OneBio SuiteSM for the integrated development, manufacturing, ... place at the Pennsylvania Convention Center in Philadelphia, from June 3-6, 2019. , ...
(Date:5/21/2019)... ... May 21, 2019 , ... ... how will we know? How can we tell it apart from the millions ... on by a multi-institution research team, including Eric Young , assistant professor ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... , ... May 03, 2019 , ... ... the President of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes ... in Brasília (DF). Urandir detailed the results of some research carried out by ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... standard, REPROCELL USA Inc. has demonstrated its ability to provide various services ... aims to enhance customer satisfaction through the effective implementation of its quality ...
(Date:5/2/2019)... , ... May 02, 2019 , ... Stay on top ... medical device and food industries. Access to all webinars is free, so be sure ... in your field! , Visit http://www.xtalks.com to see our upcoming webinars: , ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... the greater Boston area. Gone are the days of painful hair transplant procedures. ... Hair Restoration System is the only robotic intelligent solution to offer a minimally ...
Breaking Biology Technology:
Cached News: