HOME >> BIOLOGY >> NEWS
Powerful technologies probe innate immunity

A comprehensive and detailed picture of innate immunity--the human body's first line of defense against disease--is the goal of scientists funded by a recently awarded five-year, $24-million grant from the National Institute of Allergy and Infectious Diseases (NIAID).

Researchers at The Scripps Research Institute (TSRI) in La Jolla, CA, the Institute for Systems Biology (ISB) in Seattle, and Rockefeller University in New York are using techniques that straddle the divide between biology and information science to fathom the workings of innate immunity. Knowledge generated could help scientists develop treatments for septic shock, certain autoimmune disorders and diseases caused by potential agents of bioterrorism.

Daniel Rotrosen, M.D., director of NIAID's Division of Allergy, Immunology and Transplantation, notes, "The collaborators at TSRI, ISB and Rockefeller University have complementary expertise that is most impressive."

"Our goal is to develop an encyclopedia of innate immune system activity," says Richard J. Ulevitch, Ph.D., head of TSRI's immunology department and the project's principal investigator.

As its name indicates, innate immunity is inborn and provides an all-purpose defense against invasion. Innate immune system cells, including certain skin cells called Langerhans cells, arrive soon after foreign elements are detected. Some system components, called macrophages, find and engulf microorganisms, while others release chemicals that kill the organism directly. Still other cells begin recruiting specialized immune cells to the region.

Dr. Ulevitch and his co-investigators face a daunting task--identifying the thousands of genetic changes, proteins generated and biochemical pathways triggered by encounters between innate immune system cells and infectious agents. Unlike the highly specific antibodies, which are produced in almost infinite variety and which match a particular disease organism like a key in
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
9-Jan-2003


Page: 1 2 3

Related biology news :

1. Powerful machines are coming in small packages
2. Powerful new method helps reveal genetic basis of cancer
3. Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women
4. Team Solves X-ray Structure Of Powerful Enzyme
5. Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents
6. Homeland security initiative takes Memphis ORNL technologies to the nation
7. Ancient life form may help create newest technologies
8. Funding to commercialize technologies of UC San Diego engineers tops $1.2 million
9. PNNL recognized for commercializing technologies
10. Carnegie Mellon scientist says new technologies boost bio-terrorism surveillance
11. New technologies reveal mysteries of marine megafauna

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/26/2019)... ... July 25, 2019 , ... ... first mixed reality headsets to include a new generation eye tracker with hassle-free ... in Los Angeles, California (July 30 - August 1). SIGGRAPH attendees will be ...
(Date:7/23/2019)... ... , ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell company, ... person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical trial, expected ... knee. , This is the first of several planned clinical trials which ...
(Date:7/19/2019)... ... ... VetStem Biopharma has long been a leader in veterinary stem cell ... two-year research collaboration with Calidi Biotherapeutics, VetStem has signed a worldwide license and development ... be able to fast-track this cancer therapy for use in dogs due to the ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... Texas (PRWEB) , ... August 13, 2019 , ... ... Collins, Colorado to focus on prepackaged mobile phases for QC laboratories. After gaining ... Chata from its laboratory sciences approach into a valued supplier of manufacturing processing ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a clinical ... distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the 2019 ... special issue. , As the executive vice president of business development and marketing ...
(Date:7/23/2019)... ... July 22, 2019 , ... ... best-in-class services in the fields of 3D tissue imaging , digital ... Visikol initially started back in 2013 as a products company. These products are ...
(Date:7/17/2019)... (PRWEB) , ... July 16, 2019 , ... ... according to a recent report from Kalorama Information. Abbott, Roche and Siemens Healthineers ... in Kalorama Information’s latest report, Worldwide Market for Point-of-Care (POC) Diagnostics . ...
Breaking Biology Technology:
Cached News: