HOME >> BIOLOGY >> NEWS
Powerful technologies probe innate immunity

A comprehensive and detailed picture of innate immunity--the human body's first line of defense against disease--is the goal of scientists funded by a recently awarded five-year, $24-million grant from the National Institute of Allergy and Infectious Diseases (NIAID).

Researchers at The Scripps Research Institute (TSRI) in La Jolla, CA, the Institute for Systems Biology (ISB) in Seattle, and Rockefeller University in New York are using techniques that straddle the divide between biology and information science to fathom the workings of innate immunity. Knowledge generated could help scientists develop treatments for septic shock, certain autoimmune disorders and diseases caused by potential agents of bioterrorism.

Daniel Rotrosen, M.D., director of NIAID's Division of Allergy, Immunology and Transplantation, notes, "The collaborators at TSRI, ISB and Rockefeller University have complementary expertise that is most impressive."

"Our goal is to develop an encyclopedia of innate immune system activity," says Richard J. Ulevitch, Ph.D., head of TSRI's immunology department and the project's principal investigator.

As its name indicates, innate immunity is inborn and provides an all-purpose defense against invasion. Innate immune system cells, including certain skin cells called Langerhans cells, arrive soon after foreign elements are detected. Some system components, called macrophages, find and engulf microorganisms, while others release chemicals that kill the organism directly. Still other cells begin recruiting specialized immune cells to the region.

Dr. Ulevitch and his co-investigators face a daunting task--identifying the thousands of genetic changes, proteins generated and biochemical pathways triggered by encounters between innate immune system cells and infectious agents. Unlike the highly specific antibodies, which are produced in almost infinite variety and which match a particular disease organism like a key in
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
9-Jan-2003


Page: 1 2 3

Related biology news :

1. Powerful machines are coming in small packages
2. Powerful new method helps reveal genetic basis of cancer
3. Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women
4. Team Solves X-ray Structure Of Powerful Enzyme
5. Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents
6. Homeland security initiative takes Memphis ORNL technologies to the nation
7. Ancient life form may help create newest technologies
8. Funding to commercialize technologies of UC San Diego engineers tops $1.2 million
9. PNNL recognized for commercializing technologies
10. Carnegie Mellon scientist says new technologies boost bio-terrorism surveillance
11. New technologies reveal mysteries of marine megafauna

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2020)... ... March 02, 2020 , ... Nominations are now being accepted for ... Security Industry Association (SIA) and SecureIDNews and co-presented with sponsors ... Forum . The recipients of this year’s Women in Biometrics Awards will be honored ...
(Date:2/28/2020)... ... ... Meridian Clinical Research , a leading investigative research network, is a ... Clinical Trial Site. Meridian is also the largest member of Platinum Research Network ... were the result of two voting rounds, and winners will be announced at the ...
(Date:2/28/2020)... ... February 27, 2020 , ... An upcoming episode of Advancements ... maladies, such as Inflammatory Bowel Disease (IBD), specifically Crohn’s Disease (Crohn’s), and Oncology. ... a novel platform developed by Deka Biosciences, Inc. (Deka Biosciences), that will enable ...
Breaking Biology News(10 mins):
(Date:3/12/2020)... (PRWEB) , ... March 12, 2020 , ... ... of atomic force microscopy (AFM) technology, increases the business investment in Europe by ... , The Grand Opening Ceremony of the new Nanoscience Center Europe took ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... antibody products and services, today announced the launch of its FleXpress™ high-throughput ... a large number of antibodies at 80 ml scale. All production occurs ...
(Date:3/2/2020)... FREDERICK, Md. (PRWEB) , ... March 02, 2020 , ... ... Top Patent Firms 2019 list in the field of Biotechnology and Organics. , According ... counsel on a total of 259 patents issued in technology center 1600 during 2019. ...
(Date:2/21/2020)... , ... February 20, 2020 ... ... exquisite capability to perform complex, efficient and elegant chemistry. Humans have been ... to our own goals. , Through rapidly evolving technologies and strategies for ...
Breaking Biology Technology:
Cached News: