Predicting cancer patient survival with gene expression data

Cancer specialists often talk about cancer as an umbrella term for over 200 different diseases, each having unique characteristics. But even these categories are too broad, as the same type of cancer can take very different paths in different people. Researchers have traditionally diagnosed and treated cancer based on microscopic analysis of cell size and shape, a method that's especially difficult for very closely related cancers, such as non-Hodgkin's lymphoma, which has 20 subtypes. As scientists learn more about the molecular alterations in cancer, they're beginning to establish cancer subtypes based on the underlying molecular footprint of a tumor. Now Eric Bair and Robert Tibshirani describe a procedure that combines both gene expression data and the patients' clinical history to identify biologically significant cancer subtypes and show that this method is a powerful predictor of patient survival.

Their approach uses clinical data to identify a list of genes that correspond to a particular clinical factor--such as survival time, tumor stage, or metastasis--in tandem with statistical analysis to look for additional patterns in the data to identify clinically relevant subsets of genes. In many retrospective studies, patient survival time is known, even though tumor subtypes are not; Bair and Tibshirani used that survival data to guide their analysis of the microarray data. They calculated the correlation of each gene in the microarray data with patient survival to generate a list of "significant" genes and then used these genes to identify tumor subtypes. Creating a list of candidate genes based on clinical data, the authors explain, reduces the chances of including genes unrelated to survival, increasing the probability of identifying gene clusters with clinical and thus predictive significance. Such "indicator gene lists" could identify subgroups of patients with similar gene expression profiles. The lists of subgroups, based on gene expressi

Contact: Barbara Cohen
Public Library of Science

Page: 1 2

Related biology news :

1. Predicting progression of common cancers
2. Predicting the movement of genes
3. Predicting the species diversity of large herbivores in nature reserves
4. Predicting preterm birth still nearly impossible, study in New England Journal finds
5. Leader in cancer treatment and prevention research honored
6. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
7. Chemical derived from vitamin-E shows early promise as cancer drug
8. New molecular link key to cellular proteins involved in cancer progression, other diseases
9. Phase II trials of second-generation antisense cancer drug planned following successful early study
10. Trial shows which brain cancer patients benefit from temozolomide
11. Genetic differences might help distinguish thyroid cancers

Post Your Comments:

(Date:8/21/2020)... ... August 20, 2020 , ... ... Movahhed , a Clinical Operations executive with expertise in clinical trial planning and ... firm as an Expert Consultant. Throughout his career, Mr. Movahhed has helped design ...
(Date:8/7/2020)... , ... August 06, 2020 , ... ... participate in the prestigious National STEM Scholar Program, a unique professional development program ... and project support for middle school science teachers nationwide. , Created in partnership ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski ... with a near term focus on Type 2 diabetes and associated comorbidities. , ... multiple therapeutic areas and classes. As Chief Commercial Officer, Justin will lead ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health ... growth, , Known as MediVet Biologics since its formation in ... The new Ardent Animal Health will build on its base of innovative therapies ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... After research ... The completion of a great surgery is only the beginning of a successful study, ... research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license to ... move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
Breaking Biology Technology:
Cached News: