Predicting progression of comm...( tric carcinomas. In each of these three...)

Predicting progression of common cancers

tric carcinomas. In each of these three latter types of tumors, patients with tumors carrying the serum-activated wound-like genetic signature had a significantly increased risk of metastasis and death compared to patients with tumors that lacked the signature.

These results reveal a similarity between the molecular programs in normal wound healing and tumor progression and metastasis and suggest that a wound-like phenotype is a general risk factor for metastasis and aggressive behavior in many of the most common cancers. And the serum-response expression signature provides a valuable new diagnostic tool for predicting tumor behavior and determining a patient's prognosis.

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Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
13-Jan-2004

Page: 1 2
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