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Predicting progression of common cancers

tric carcinomas. In each of these three latter types of tumors, patients with tumors carrying the serum-activated wound-like genetic signature had a significantly increased risk of metastasis and death compared to patients with tumors that lacked the signature.

These results reveal a similarity between the molecular programs in normal wound healing and tumor progression and metastasis and suggest that a wound-like phenotype is a general risk factor for metastasis and aggressive behavior in many of the most common cancers. And the serum-response expression signature provides a valuable new diagnostic tool for predicting tumor behavior and determining a patient's prognosis.


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Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
13-Jan-2004


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