HOME >> BIOLOGY >> NEWS
Presence of only two genes makes the difference between an ordinary and headless embryo

It only takes two genes to make the difference between an ordinary embryo and one that develops without a head.

At least, that is the case in the zebrafish, a team of geneticists from Vanderbilt University report in the Dec. 15 issue of the journal Genes & Development. According to the papers senior author, Lilianna Solnica-Krezel, something similar is likely to hold true for mammals and humans. One of these genes has an equivalent in human development; the other one were not sure of, says the assistant professor of biological sciences at Vanderbilt.

This is the latest in a series of recent studies that have begun to unravel the mysteries of development at the molecular level. For hundreds of years scientists have wondered how an early embryo that is made up of identical, undifferentiated cells, can develop into nerves, muscles, lungs and other organs. Answers to this question may lead to new treatments for birth defects and other illnesses caused by defective development.

The picture that is emerging is one of elegant simplicity. The cells in the embryo secrete a protein called bone morphogenetic protein, or BMP. A structure, called the (Spemann) gastrula organizer, forms on the eggs surface in what will become the dorsal, or backside of the animal. The organizer becomes a source of negative regulators of BMPproteins that reduce its production or function. This interaction produces variations in the concentration of BMP in different parts of the embryo, providing instructions that effectively determine top and bottom, left and right, front and back. The cells then use this information to begin differentiating into various types of tissue and to move to appropriate locations within the developing embryo.

Where BMP concentrations are lowest, cells develop into nervous tissue and backbone and where they are highest cells tend to become skin, blood and tail, Solnica-Krezel observes. (In 1992, Brigid L. M. Hogan, the Hortense B. Ingram Chair in Molecula
'"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
14-Dec-2000


Page: 1 2

Related biology news :

1. Presence of certain tumor markers for melanoma could signal best results for vaccine
2. Presence of a fertile female in the next nest can lead a bird astray, UB research finds
3. Enzyme Presence Could Be Key Factor In Wolf Health, Study Suggests
4. Silent Thunder: In The Presence Of Elephants
5. Presence Of Protein Extends Life; Potential Aging Mechanism Found
6. Belgian researchers explore revolutionary approach to angiogenesis
7. Tracing genes, biologists show lizard migration is traced to Florida
8. Certain genes boost fish oils protection against breast cancer
9. Fossil genes reveal how life sheds form and function
10. Missing genes may help explain why plague bacteria are so deadly
11. Do genes respond to global warming?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, ... President and CEO has been named one of the 100 most inspiring individuals ... PharmaVoice 100 honorees are selected based on how they have inspired their colleagues ...
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
Breaking Biology Technology:
Cached News: