HOME >> BIOLOGY >> NEWS
Presence of only two genes makes the difference between an ordinary and headless embryo

It only takes two genes to make the difference between an ordinary embryo and one that develops without a head.

At least, that is the case in the zebrafish, a team of geneticists from Vanderbilt University report in the Dec. 15 issue of the journal Genes & Development. According to the papers senior author, Lilianna Solnica-Krezel, something similar is likely to hold true for mammals and humans. One of these genes has an equivalent in human development; the other one were not sure of, says the assistant professor of biological sciences at Vanderbilt.

This is the latest in a series of recent studies that have begun to unravel the mysteries of development at the molecular level. For hundreds of years scientists have wondered how an early embryo that is made up of identical, undifferentiated cells, can develop into nerves, muscles, lungs and other organs. Answers to this question may lead to new treatments for birth defects and other illnesses caused by defective development.

The picture that is emerging is one of elegant simplicity. The cells in the embryo secrete a protein called bone morphogenetic protein, or BMP. A structure, called the (Spemann) gastrula organizer, forms on the eggs surface in what will become the dorsal, or backside of the animal. The organizer becomes a source of negative regulators of BMPproteins that reduce its production or function. This interaction produces variations in the concentration of BMP in different parts of the embryo, providing instructions that effectively determine top and bottom, left and right, front and back. The cells then use this information to begin differentiating into various types of tissue and to move to appropriate locations within the developing embryo.

Where BMP concentrations are lowest, cells develop into nervous tissue and backbone and where they are highest cells tend to become skin, blood and tail, Solnica-Krezel observes. (In 1992, Brigid L. M. Hogan, the Hortense B. Ingram Chair in Molecula
'"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
14-Dec-2000


Page: 1 2

Related biology news :

1. Presence of certain tumor markers for melanoma could signal best results for vaccine
2. Presence of a fertile female in the next nest can lead a bird astray, UB research finds
3. Enzyme Presence Could Be Key Factor In Wolf Health, Study Suggests
4. Silent Thunder: In The Presence Of Elephants
5. Presence Of Protein Extends Life; Potential Aging Mechanism Found
6. Belgian researchers explore revolutionary approach to angiogenesis
7. Tracing genes, biologists show lizard migration is traced to Florida
8. Certain genes boost fish oils protection against breast cancer
9. Fossil genes reveal how life sheds form and function
10. Missing genes may help explain why plague bacteria are so deadly
11. Do genes respond to global warming?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... Baltimore, Maryland (PRWEB) , ... August 21, 2017 ... ... has partnered with a leading Chinese bio security firm, to bring its proprietary ... As part of the relationship, the Chinese firm has purchased an undisclosed ...
(Date:8/18/2017)... ... August 18, 2017 , ... OAI, a leading Silicon ... Microfluidics Industries, announces the new Model 800E front and backside, semi-automatic mask aligner ... mask aligners. OAI has already received and installed several orders for the ...
(Date:8/16/2017)... ... August 16, 2017 , ... Recent ... cell type. Many treatments for specific cancers, such as breast, prostate, or lung, ... is androgen deprivation therapy for advanced prostate cancer. , This therapy limits ...
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017  Kingfisher Talent, ... search and leadership development, and Virdis Group, global executive search ... exclusive alliance that enables clients to leverage the expertise and ... "For our clients here in the Boston ... diverse population of leadership talent throughout the US, ...
Breaking Biology Technology:
Cached News: