HOME >> BIOLOGY >> NEWS
Process triggered by some anti-cancer drugs causes tumors in mice, study finds

CAMBRIDGE, Mass. It is well known that cancers frequently are caused by genetic mutations random alterations along the long chain of molecules that make up the sequence of an organisms DNA. Two studies published this week in Science now point to another culprit in tumor formation, a process that can cause chromosomes to become unstable by affecting changes in the methylation of the DNA, which renders a gene active or inactive by affecting how the DNA is packaged into proteins without changing gene sequences.

The findings are important, researchers say, because some anti-cancer drugs in clinical trials are designed to kill diseased cells by triggering the process under study called hypomethylation which lowers the level of methylation. Previous studies by scientists at Whitehead Institute for Biomedical Research have shown that drug-induced hypomethylation can protect against tumors arising in the intestinal tract (colon cancer). But in this new work, Whitehead scientists found that hypomethylation also may cause tumors in mice, suggesting that such drugs may do harm as well as good, said Rudolf Jaenisch, leader of the team that published these new studies.

You have to know how you interfere with these cancer mechanisms, said Jaenisch, adding that the same alteration of cellular chemistry that controls some cancers is now seen to cause cancer in other tissues. At the moment we have two totally opposite results when we look in two different tissues. In the intestines, hypomethylation protects against cancer, and in the thymus it enhances cancer.

As researchers search for explanations for what prompts cancer cells to proliferate and grow, an increasing number have begun to examine extra-genetic changes problems that affect whether a gene is active or silent not the genes sequence. One process receiving heavy scrutiny is among the most basic events in a cells nucleus during the life of the cell, methylation, during which methyl molecules,
'"/>

Contact: Kelli Whitlock or Melissa Withers
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
17-Apr-2003


Page: 1 2 3

Related biology news :

1. Scientists share multidisciplinary discoveries at Earth System Processes
2. International scientists probe unsolved puzzles of the Earth and beyond at "Earth System Processes"
3. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
4. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
5. Researchers Identify Molecule That May Be Key In Pheromone Processing
6. New Coating Process May Prevent Body From Rejecting Medical Implants
7. Innovative Process To Benefit Ground Water Clean-Up
8. INDOEX Researchers Document The Impact Of Pollutants On Climate Processes Over The Tropical Indian Ocean
9. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms
10. Common Prostate Cancer: A Different Process Altogether?
11. Penn State Engineers Develop New Simulation For Ultrafine Particle Growth Process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: