HOME >> BIOLOGY >> NEWS
Process triggered by some anti-cancer drugs causes tumors in mice, study finds

s; when methylation was reduced in such mice, Eden found that they developed soft-tissue sarcomas earlier when compared to similarly mutated mice with normal methylation levels. In these mice, Eden could show that hypomethylation-induced chromosomal instability caused an increase in tumor formation.

The instability could be an asset to a cancer cell looking to multiply and cause trouble, Jaenisch said. There seems to be a selective advantage for tumor cells to be hypomethylated, because its chromosomes are more unstable.

The data offer real food for thought about the role of losing methylation in cancer, noted Stephen Baylin, a scientist at John Hopkins University in Baltimore, Md. But Baylin also cautioned that these findings in mice may not be seen in people. In the mice engineered at Whitehead Institute, the level of methylation likely was more reduced than in most human tumors. Moreover, he cautioned that unlike hypomethylation induced in cancers that develop in human adults, these hypomethylated mice carry a reduced methylation capacity for their entire lives, starting at the embryonic stage.

Jaenisch may be right, Baylin said, but you have to be very careful about equating the situation that hes looking at experimentally with whats going on in human tumors, an assertion also made by Jaenisch.

It is very important to assess whether findings made in animal models apply to patients, Jaenisch said.

Jaenischs lab plans to extend this work by looking at other tumors, such as those of the pancreas, breast and liver, changing methylation levels and observing the results. I think it will reveal metabolic differences between tissues, he said, and may lead to a deeper understanding why reducing methylation levels seems to harm some cancers and benefit others.


'"/>

Contact: Kelli Whitlock or Melissa Withers
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
17-Apr-2003


Page: 1 2 3

Related biology news :

1. Scientists share multidisciplinary discoveries at Earth System Processes
2. International scientists probe unsolved puzzles of the Earth and beyond at "Earth System Processes"
3. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
4. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
5. Researchers Identify Molecule That May Be Key In Pheromone Processing
6. New Coating Process May Prevent Body From Rejecting Medical Implants
7. Innovative Process To Benefit Ground Water Clean-Up
8. INDOEX Researchers Document The Impact Of Pollutants On Climate Processes Over The Tropical Indian Ocean
9. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms
10. Common Prostate Cancer: A Different Process Altogether?
11. Penn State Engineers Develop New Simulation For Ultrafine Particle Growth Process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
Breaking Biology News(10 mins):
(Date:7/22/2018)... WESTMINSTER, Colo. (PRWEB) , ... July 21, 2018 , ... ... recent research workshop on the off-target movement of dicamba herbicides is available on the ... research protocols that will help all stakeholders better understand and manage factors contributing to ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a United States multicenter, prospective clinical study that demonstrates the accuracy ... test capable of identifying clinically significant acute bacterial and viral respiratory tract ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... its endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression ... guides is transformative for performing systematic gain-of-function studies. , This complement to ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017  SkylineDx ... London (ICR) and University of Leeds ... to risk-stratify patients with multiple myeloma (MM), in a multi-centric ... The University of Leeds is the ... UK, and ICR will perform the testing services to include ...
Breaking Biology Technology:
Cached News: