HOME >> BIOLOGY >> NEWS
Process triggered by some anti-cancer drugs causes tumors in mice, study finds

s; when methylation was reduced in such mice, Eden found that they developed soft-tissue sarcomas earlier when compared to similarly mutated mice with normal methylation levels. In these mice, Eden could show that hypomethylation-induced chromosomal instability caused an increase in tumor formation.

The instability could be an asset to a cancer cell looking to multiply and cause trouble, Jaenisch said. There seems to be a selective advantage for tumor cells to be hypomethylated, because its chromosomes are more unstable.

The data offer real food for thought about the role of losing methylation in cancer, noted Stephen Baylin, a scientist at John Hopkins University in Baltimore, Md. But Baylin also cautioned that these findings in mice may not be seen in people. In the mice engineered at Whitehead Institute, the level of methylation likely was more reduced than in most human tumors. Moreover, he cautioned that unlike hypomethylation induced in cancers that develop in human adults, these hypomethylated mice carry a reduced methylation capacity for their entire lives, starting at the embryonic stage.

Jaenisch may be right, Baylin said, but you have to be very careful about equating the situation that hes looking at experimentally with whats going on in human tumors, an assertion also made by Jaenisch.

It is very important to assess whether findings made in animal models apply to patients, Jaenisch said.

Jaenischs lab plans to extend this work by looking at other tumors, such as those of the pancreas, breast and liver, changing methylation levels and observing the results. I think it will reveal metabolic differences between tissues, he said, and may lead to a deeper understanding why reducing methylation levels seems to harm some cancers and benefit others.


'"/>

Contact: Kelli Whitlock or Melissa Withers
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
17-Apr-2003


Page: 1 2 3

Related biology news :

1. Scientists share multidisciplinary discoveries at Earth System Processes
2. International scientists probe unsolved puzzles of the Earth and beyond at "Earth System Processes"
3. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
4. Trash From Crop-Processing Plant Harvested For Disease-Fighting Agents
5. Researchers Identify Molecule That May Be Key In Pheromone Processing
6. New Coating Process May Prevent Body From Rejecting Medical Implants
7. Innovative Process To Benefit Ground Water Clean-Up
8. INDOEX Researchers Document The Impact Of Pollutants On Climate Processes Over The Tropical Indian Ocean
9. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms
10. Common Prostate Cancer: A Different Process Altogether?
11. Penn State Engineers Develop New Simulation For Ultrafine Particle Growth Process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They ... a complex biological network, a depiction of a system of linkages and connections ... Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) and ...
(Date:10/12/2017)... ca (PRWEB) , ... October 12, 2017 , ... ... the Surgical Wound Market with the addition of its newest module, US Hemostats ... $1.2B market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity ... for performing systematic gain-of-function studies. , This complement to loss-of-function studies, such ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
Breaking Biology Technology:
Cached News: