HOME >> BIOLOGY >> NEWS
Profiling prostate cancer

Determining proper treatment for individuals diagnosed with prostate cancer suffers because of the current unreliability of methods to predict the clinical course of the disease. Existing procedures for patient stratification include a series of clinical, biochemical, and histopathological examinations, such as prostate specific antigen (PSA) levels, tumor stage, Gleason score, and genetic approaches that look for specific oncogenic alterations. Used together, these tools still have only limited classification capability. Recent studies utilizing cDNA microarray technology have indicated that specific genetic markers may be useful as potential prostate cancer markers. In the March 15 issue of the Journal of Clinical Investigation, Gennadi Glinsky and colleagues, from the Sydney Kimmel Cancer Center, San Diego, CA, present a highly accurate gene-expression-based prostate cancer recurrence predictor algorithm. The authors used a microarray-based gene-expression profiling method to determine molecular signatures that could distinguish subgroups of patients with different disease outcomes. The algorithm was developed utilizing an analysis that assessed expression profiles of over 12,000 genes from 100 different tumors. Five highly discriminating gene-expression clusters were assigned from this analysis and then tested on a new set of 79 patients. Of those patients who ultimately had recurrence of prostate cancer, the algorithm correctly classified 88% of these patients into the poor-prognosis group. This study provides a significant advance in our ability to properly classify the clinical outcome of prostate cancer patients for use in determining appropriate treatment.

In an accompanying commentary, Mitchell Benson and James McKiernan of Columbia University, place this study in context with other methods for predicting clinical outcome, and how combination of these methods with that presented here should enhance our ability to stratify patient populati
'"/>

Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2004


Page: 1 2

Related biology news :

1. Profiling the genes that make stem cells
2. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
3. Researchers identify distinctive signature for metastatic prostate cancer
4. Charting the future in prostate cancer care: A call to action
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study narrows search for genes placing men at increased risk for prostate cancer
7. MICs shed light on prostate cancer
8. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
9. New prostate cancer gene identified
10. U-M scientists find common virus in human prostate tissue
11. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/16/2018)... ... November 16, 2018 , ... ... awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby Advocacy Award at the ... Award, named “The Selby” after longtime IBWA contributor Shayron Barnes-Selby, is awarded to ...
(Date:11/15/2018)... ... 14, 2018 , ... Persivia, a provider of real-time bundled ... Healthcare, a leading operator of over 50 hospitals nationwide, has selected Persivia’s Bundled ... solution consists of the industry’s only end to end solution for succeeding in ...
(Date:11/14/2018)... ... November 14, 2018 , ... In recognition of World Diabetes ... diabetes awareness and advocacy. The company is reaching out to help educate patients and ... emphasize the importance of vision testing for people with the disease. , The American ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ... 05, 2018 , ... The incredible life story of former refugee and LG ... by Carlos Moedas, the European Commissioner for Research and Innovation. , In his ... Lives, Commissioner Moedas spoke at length of Yousef’s life and journey, citing the man ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi ... the height of truffle season. , Her first stop was Umbria, a ... the exclusive Black Truffle Lodge in the small mountain village of Pettino, Chef Jodi ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy ... from Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers ... for the last 20 years. He now offers skilled dental care in two practice ...
(Date:11/13/2018)... ... , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering VetStem ... of Kahala Pet Hospital on Oahu, is a skilled surgeon who has ... island of Kauai on an almost weekly basis to perform surgery at Kapaa ...
Breaking Biology Technology:
Cached News: