HOME >> BIOLOGY >> NEWS
Programmable Cells Open Window Of Opportunity For Gene Therapy

DETROIT -- "Any cell can be reprogrammed, and this process is reversible. You do not need to start with the stem cell." These remarks and the research behind them, which could have a profound impact on gene therapy, come from Wayne State University researcher Stephen Krawetz, Ph.D., who reported his findings in the December issue of Development.

In the fast-paced world of genetics research, Dr. Krawetz, associate professor of obstetrics and gynecology and the Center for Molecular Medicine and Genetics at the WSU School of Medicine, has begun to unravel the mechanism that is responsible for the direction each cell takes in its development from the generic cells of the embryo to the specific cells of each tissue.

His findings also provide an insight into the previously unknown mechanism behind the creation of Dolly, the first animal cloned from adult cells. "They knew the cells were reprogrammed, but they had no idea of the mechanism," Dr. Krawetz said. He has identified the mechanism and has learned how it works. The ramifications for gene therapy are tremendous, he remarked. "It is our expectation that by using this new technology, we may be able to selectively open and express genes, or close and silence genes in populations of differentiating and/or replicating cells. Harnessing this potential to specifically change cell type will resolve some of the problems faced in bringing gene therapy from the bench to the bedside."

To discover the mechanism responsible for cell reprogramming, he studied the spermatogenesis pathway, which creates sperm cells, and the point at which the genes in the cell are available for expression. He described this process is "naturally expressive," because it readies a select subset of genes from the genome for expression. The fate of the cell, then, is determined by the repertoire of these readied, or "potentiated" genes.

Dr. Krawetz's main task was to determine how this mechanism "potentiation" arises. He beg
'"/>

Contact: Stephen Krawetz, Ph.D.
steve@compbio.med.wayne.edu
313-577-6770
Wayne State University School of Medicine
28-Jan-1999


Page: 1 2

Related biology news :

1. Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
2. Cells may shoot messenger to halt protein production
3. Cells from adult bone marrow can be converted into brain stem cells for transplantation
4. Cells ability to open bloods floodgates hinges on unexpected factors
5. Cells ability to live without oxygen give clues for treating major diseases
6. Cells use patch to heal tears, avoid destruction and disease
7. Food for thought: Cells dine on their own brains to stay fit and trim
8. Cells in patients noses hold potential to restore function in spinal cord injury
9. Cells on the verge of suicide
10. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
11. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2016)... 2016  xG Technology, Inc. ("xG" or the "Company") ... communications for use in challenging operating environments, announced its ... Management will hold a conference call to discuss these ... Time (details below). Key Recent Accomplishments ... binding agreement to acquire Vislink Communication Systems. The purchase ...
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/9/2016)... 9, 2016  Perkotek an innovation leader in attendance control systems is proud to ... hours, for employers to make sure the right employees are actually signing in, and ... ... ... ...
Breaking Biology News(10 mins):
(Date:11/30/2016)...  GenomOncology today announced the appointment of Joshua F. ... Dr. Coleman will oversee clinical content development and ... The GenomOncology software suite empowers molecular pathologists with a seamless ... decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... 30, 2016 /PRNewswire/ -  Equicare Health Inc ., the ... recognized as one of the top 100 companies in ... listing that distinguishes the top digital health companies across ... step forward this year continually upgrading our product with ... base and team," says Len Grenier , CEO ...
(Date:11/30/2016)...   Merck , a leading science and technology ... set of agreements with Evotec AG, whereby Evotec AG ... reagents such as CRISPR and shRNA libraries. Combining access ... accelerated pathway to explore and identify new drug targets. ... new targets, a process that can be time- and ...
(Date:11/30/2016)... ... 2016 , ... With growth rates averaging more than 30% each year, Random42 ... to continuing their expansion in their new office space. The new office has a ... by the creative industries, so Random42 Scientific Communication will fit right in. , ...
Breaking Biology Technology:
Cached News: