HOME >> BIOLOGY >> NEWS
Programmable Cells Open Window Of Opportunity For Gene Therapy

DETROIT -- "Any cell can be reprogrammed, and this process is reversible. You do not need to start with the stem cell." These remarks and the research behind them, which could have a profound impact on gene therapy, come from Wayne State University researcher Stephen Krawetz, Ph.D., who reported his findings in the December issue of Development.

In the fast-paced world of genetics research, Dr. Krawetz, associate professor of obstetrics and gynecology and the Center for Molecular Medicine and Genetics at the WSU School of Medicine, has begun to unravel the mechanism that is responsible for the direction each cell takes in its development from the generic cells of the embryo to the specific cells of each tissue.

His findings also provide an insight into the previously unknown mechanism behind the creation of Dolly, the first animal cloned from adult cells. "They knew the cells were reprogrammed, but they had no idea of the mechanism," Dr. Krawetz said. He has identified the mechanism and has learned how it works. The ramifications for gene therapy are tremendous, he remarked. "It is our expectation that by using this new technology, we may be able to selectively open and express genes, or close and silence genes in populations of differentiating and/or replicating cells. Harnessing this potential to specifically change cell type will resolve some of the problems faced in bringing gene therapy from the bench to the bedside."

To discover the mechanism responsible for cell reprogramming, he studied the spermatogenesis pathway, which creates sperm cells, and the point at which the genes in the cell are available for expression. He described this process is "naturally expressive," because it readies a select subset of genes from the genome for expression. The fate of the cell, then, is determined by the repertoire of these readied, or "potentiated" genes.

Dr. Krawetz's main task was to determine how this mechanism "potentiation" arises. He beg
'"/>

Contact: Stephen Krawetz, Ph.D.
steve@compbio.med.wayne.edu
313-577-6770
Wayne State University School of Medicine
28-Jan-1999


Page: 1 2

Related biology news :

1. Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
2. Cells may shoot messenger to halt protein production
3. Cells from adult bone marrow can be converted into brain stem cells for transplantation
4. Cells ability to open bloods floodgates hinges on unexpected factors
5. Cells ability to live without oxygen give clues for treating major diseases
6. Cells use patch to heal tears, avoid destruction and disease
7. Food for thought: Cells dine on their own brains to stay fit and trim
8. Cells in patients noses hold potential to restore function in spinal cord injury
9. Cells on the verge of suicide
10. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
11. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Programmable Cells Open Window Opportunity For Gene Therapy

(Date:8/27/2014)... FREMONT, Calif. , Aug. 27, 2014  WaferGen ... completed its previously announced underwritten public offering of units ... $10,000 per unit for gross proceeds of $20 million, ... expenses payable by the Company.  The shares and warrants ... Each unit sold in the offering consists ...
(Date:8/27/2014)... researchers have identified a gene that could help scientists ... protein in the cell membrane of plants that senses ... conservation machinery accordingly. , "It,s similar to a ... at Duke. , The findings, which appear Aug. ... it easier to feed the world,s growing population in ...
(Date:8/27/2014)... manipulating neural circuits in the brain of mice, ... memories. The research, led by Howard Hughes Medical ... of Technology (MIT), reveals that the connections between ... information about an experience and the part of ... that experience are malleable. , Altering those ...
Breaking Biology News(10 mins):WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Water 'thermostat' could help engineer drought-resistant crops 2Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
(Date:8/27/2014)... , Aug. 27, 2014 ... the "Global Lactic Acid  (Biodegradable Polymer, Food ... Trends & Forecasts to 2019" report to ... simplest hydroxyl-carboxylic acid with an asymmetrical carbon atom. ... the biodegradable polymer, food and beverage, personal care ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
Cached News: