HOME >> BIOLOGY >> NEWS
Programmable Cells Open Window Of Opportunity For Gene Therapy

DETROIT -- "Any cell can be reprogrammed, and this process is reversible. You do not need to start with the stem cell." These remarks and the research behind them, which could have a profound impact on gene therapy, come from Wayne State University researcher Stephen Krawetz, Ph.D., who reported his findings in the December issue of Development.

In the fast-paced world of genetics research, Dr. Krawetz, associate professor of obstetrics and gynecology and the Center for Molecular Medicine and Genetics at the WSU School of Medicine, has begun to unravel the mechanism that is responsible for the direction each cell takes in its development from the generic cells of the embryo to the specific cells of each tissue.

His findings also provide an insight into the previously unknown mechanism behind the creation of Dolly, the first animal cloned from adult cells. "They knew the cells were reprogrammed, but they had no idea of the mechanism," Dr. Krawetz said. He has identified the mechanism and has learned how it works. The ramifications for gene therapy are tremendous, he remarked. "It is our expectation that by using this new technology, we may be able to selectively open and express genes, or close and silence genes in populations of differentiating and/or replicating cells. Harnessing this potential to specifically change cell type will resolve some of the problems faced in bringing gene therapy from the bench to the bedside."

To discover the mechanism responsible for cell reprogramming, he studied the spermatogenesis pathway, which creates sperm cells, and the point at which the genes in the cell are available for expression. He described this process is "naturally expressive," because it readies a select subset of genes from the genome for expression. The fate of the cell, then, is determined by the repertoire of these readied, or "potentiated" genes.

Dr. Krawetz's main task was to determine how this mechanism "potentiation" arises. He beg
'"/>

Contact: Stephen Krawetz, Ph.D.
steve@compbio.med.wayne.edu
313-577-6770
Wayne State University School of Medicine
28-Jan-1999


Page: 1 2

Related biology news :

1. Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
2. Cells may shoot messenger to halt protein production
3. Cells from adult bone marrow can be converted into brain stem cells for transplantation
4. Cells ability to open bloods floodgates hinges on unexpected factors
5. Cells ability to live without oxygen give clues for treating major diseases
6. Cells use patch to heal tears, avoid destruction and disease
7. Food for thought: Cells dine on their own brains to stay fit and trim
8. Cells in patients noses hold potential to restore function in spinal cord injury
9. Cells on the verge of suicide
10. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
11. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Programmable Cells Open Window Opportunity For Gene Therapy

(Date:11/5/2014)... professor of biology in the UTSA College of ... nation selected to receive a two-year $300,00 National ... Research (EAGER). The funding supports President Obama,s BRAIN ... create new technology that will demystify complex brain ... in neuroscience are broken into the interactions of ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
(Date:11/21/2014)... Calif. (PRWEB) November 20, 2014 ... nonprofit, public policy research organization representing leading California ... firms, and PwC US today released ... in life sciences industry growth. The trend shows ... The 2015 California Biomedical Industry Report ...
(Date:11/21/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Sodium ... like its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... US, Europe, Asia, China, Japan etc. regions) industry ...
(Date:11/21/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced results ... 2014.  Biorem,s complete 2014 third quarter financial statements and MD&A have ... ended September 30, , Nine-months ended September ... 2014 , 2013 , 2014 , ... , 6,715 , 14,476 Gross profit , ...
(Date:11/18/2014)... Diego, CA (PRWEB) November 17, 2014 Athena ... of Salk , Dr. Beverly Emerson, a professor in the ... of genes. Her most recent discovery points to an “off ... Dr. Emerson’s career and how her local research is making ... will present her findings and then join host Cheryl K. ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
Cached News: