HOME >> BIOLOGY >> NEWS
Promising biomarker for melanoma is identified

o 18 years in some patients."

"In cancer research there is a great deal of focus on finding these kinds of molecular markers because we need more reliable means of assessing the risk of cancer recurrence," adds Dr. Polsky, a dermatologist and Associate Director of the NYU Department of Dermatology's Pigmented Lesion Section. "Our findings need to be verified independently by other groups before this marker could be used in the clinic," he says.

The researchers tracked levels of HDM2 using an antibody technique that tags the molecule with a colored stain. The molecule is involved in the pathway for a tumor suppressor gene called p53, which, when mutated, is associated with many cancers but not melanoma. It is not clear why HDM2 levels would be high in people with melanoma, says Dr. Polsky.

The incidence of melanoma continues to rise and this year it is expected to strike 53,600 people in the United States, and some 7,400 people with the disease are expected to die, according to the American Cancer Society. Melanoma is the ninth most common cancer in the United States. Excessive exposure to sunlight, a fair complexion, and a family history of melanoma, among other factors, place people at higher risk for the disease. With early detection and treatment, melanoma is highly curable.

Currently, the thickness of a melanoma at the time of diagnosis, sometimes combined with a procedure called sentinel node biopsy, is used to assess whether a patient's tumor will recur and if additional treatment with immunotherapy is warranted after the cancer is removed. Patients with early stage melanoma, called stage I cancer, have the thinnest lesions and are therefore the least likely to have a recurrence of their original cancer.

The prognosis usually worsens as the tumor extends deeper into the skin. However, levels of HDM2 in the study did not correlate with tumor thickness. "Tumor thickness is not enough," says
'"/>

Contact: Marjorie Shaffer
Marjorie.Shaffer@med.nyu.edu
212-404-3555
New York University Medical Center and School of Medicine
3-Dec-2002


Page: 1 2 3

Related biology news :

1. Promising hospital anti-infection strategy probably wont work, study shows
2. Promising research: From employment issues to virology
3. Promising new tool shows how dividing cells finish what they start
4. Promising multi-strain HIV vaccine candidate emerges
5. Promising new therapies for deadly form of leukemia
6. Dr. Robert C. Gallo to Collaborate with Visiting Israeli Scientist on Promising HIV Vaccine Research at Marylands Institute of Human Virology
7. SFU Spin-Off Company To Research Promising Antibacterial Agents
8. SFU Molecular Biologist Pursues Promising New Way To Fight Disease
9. UNC-CH Researchers Develop Promising Heart Research Tool
10. Duke Researchers Call Gene Therapy A Promising Strategy For Sickle Cell Anemia
11. Promising Fatty Acid Research Leads To MS Clinical Trial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... GREEN, Ohio (PRWEB) , ... ... ... Engineered Products , a global leader in the design and manufacturer of ... selection of seating and adjustable footrests compliant with Healthier Hospital Initiative guidelines. ...
(Date:11/9/2019)... ... November 08, 2019 , ... SiteSeer Technologies, creator of SiteSeer Professional ... new client and user of SiteSeer. The boutique real estate developer of single and ... use SiteSeer to supplement its own analysis of markets. , Geoffrey Kerth, manager ...
(Date:11/6/2019)... , ... November 06, 2019 , ... ... version 2.0 today. The Genomic Search Engine now includes the ability to search ... further accelerate diagnosis of patients with genetic and rare diseases. , Patients, particularly ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... Western University of ... innovation and technology play in educating the next generation of health care providers. ... and presentations by WesternU administrators and representatives of companies working with the University ...
(Date:10/26/2019)... ... October 24, 2019 , ... ... Medical Marketing Group (BMMG), a boutique healthcare-specific marketing firm, to strengthen the ... in-house Healthcare Strategy Division. , Healthcare clients in pharma, bio-therapeutics, medical device and ...
(Date:10/22/2019)... ... October 22, 2019 , ... ... announced that its lead program, DBI-001, met its primary safety endpoints, with no ... phase 2a clinical trial for the treatment of interdigital tinea pedis (athlete’s foot). ...
(Date:10/10/2019)... , ... October 09, 2019 , ... ... Abernethy, MD, PhD, Principal Deputy Commissioner, FDA, as a newly-confirmed keynote speaker for ... 2019 in Las Vegas, Nevada USA. , Dr. Abernethy, a hematologist/oncologist and palliative ...
Breaking Biology Technology:
Cached News: