HOME >> BIOLOGY >> NEWS
Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs

DURHAM, N.C. -- A team of molecular biologists has pinpointed a genetic switch in prostate cancer cells that may play a role in triggering a quiescent tumor to erupt into an invasive, deadly cancer that spreads throughout the body.

The scientists said discovery of this single genetic switch could open a research pathway that might well lead to a road map of the complex changes prostate cancer cells undergo in their progression to a deadly form. Such a road map would yield not only molecular markers that would allow physicians to better pinpoint the stage of a prostate cancer, but also new drugs to kill cancer cells at earlier stages, the researchers said.

Prostate cancers are distinguished by their tendency to linger at a relatively benign stage for many years, but to suddenly transform into a deadly form that spreads, or metastasises, throughout the body.

The scientists are Russ Carstens and Mariano Garcia-Blanco of the Duke University Medical Center department of pharmacology and cancer biology, and Wallace McKeehan of Texas A&M University. They published their findings in the April issue of Molecular and Cellular Biology. Their work is supported by the National Institutes of Health, the Duke Comprehensive Cancer Center, the American Heart Association and the Keck Foundation, which supports the Levine Science Research Center, where the work was performed.

Working with rat prostate cancer cells, the scientists discovered the molecular basis for a genetic switch that governs whether a cancer cell generates one or another form of a protein receptor molecule called FGF-R2 (Fibroblast Growth Factor Receptor 2) that festoons the surface of the cell.

These receptors are molecular locks, into which fits a protein called a growth factor, secreted by another cell in the prostate. As long as the FGF-R2 receptor is of one type -- called IIIb -- the cancer cell is relatively
'"/>

Contact: Dennis Meredith
Dennis@dukenews.duke.edu
919-681-8054
Duke University
25-Mar-1998


Page: 1 2 3

Related biology news :

1. Prostate cancer test works as well for black men, study shows
2. Renowned Prostate Cancer Experts Present Latest Findings At UCSF Cancer Center Symposium
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Common Prostate Cancer: A Different Process Altogether?
5. Plant-Based Fat May Reduce Risk Of Prostate Cancer By Altering Testosterone Metabolism, UB Study Shows
6. Study Of Protein Reveals Two Different Prostate Cancers;One More Deadly Also Shows That Benign Prostate Hyperplasia Not A Precursor To Prostate Cancer
7. Penn Researchers Find Mutation In Prostate Cancer Gene
8. A New Molecular Marker For Prostate Cancer
9. Duration Of Pre-Clinical Prostate Cancer Based On Serial PSA Data From The VA Normative Aging Study
10. PSA Levels Mean More Extensive Prostate Disease In Older Men
11. New Test May Reduce Need For Some Prostate Cancer Biopsies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2019)... ... June 27, 2019 , ... Lighting designers from integrated design firm ... honored the designers for creating both engaging and energy efficient lighting systems. , The ... office tower in San Diego, California earned an IES Illumination Award of Merit in ...
(Date:6/18/2019)... ... June 18, 2019 , ... Cirrascale Cloud ... Data Science Workstations-as-a-Service as part of its dedicated, multi-GPU, deep learning cloud offerings. ... Science Workstations feature NVIDIA® Quadro RTX™ GPUs for up to 260 teraflops of ...
(Date:6/13/2019)... ... June 13, 2019 , ... Global Clinical and Ancillary Supply ... clinical and ancillary supply chain management needs of large- and middle-market pharmaceutical, biotechnology, ... announced it will sponsor a summer education program offered by the Young Men ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... , ... June 12, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging ... has been signed. The agreement will grant exclusive rights for Zillion to represent ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative Medicine company, ... has announced that their GMP facility for cell production is now approved by ... This is an important milestone for VetStem as it expands into contract cell ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... Data Integrity on July 08-09, 2019 in Boston, MA. This peer recommended interactive ... device organizations. , The training will kick off with a compendial treatment of ...
(Date:5/15/2019)... ... May 15, 2019 , ... Milton Hershey School® has ... for his work within the biomedical industry, where he is changing lives by creating ... , “William Harding epitomizes the vision of our founders – Milton and Catherine ...
Breaking Biology Technology:
Cached News: