HOME >> BIOLOGY >> NEWS
Protective mechanism exploited by tumors may provide new cancer treatment

Like a parasite exploiting its host, some tumors protect themselves by recruiting non-tumor cells that normally help keep the immune system in check, say researchers at the Medical College of Georgia.

When the researchers looked into the lymph nodes where tumors drain typically the first place tumors spread they found a subset of normal host immune cells were expressing IDO, an immunosuppressive enzyme also expressed by the fetus to help avoid rejection by the mother's immune system.

They also found that when they gave a drug to block IDO expression, the immune system rallied.

"Our hypothesis in this situation was that the bad guys in this case were actually cells from the host, perfectly normal cells that had, in a sense, been requested by the tumor," says Dr. David Munn, pediatric hematologist-oncologist and lead author on the study published in the July 15 issue of Journal of Clinical Investigation.

Now they have shown in an animal model that these normal cells are a type of dendritic cell that was previously ignored by the scientists because they believed the cells were involved in making antibodies not in suppressing the immune system. By recognizing the actual role of these previously discarded cells, the MCG scientists and their collaborators have moved significantly closer to using this approach to help cancer patients.

"We have demonstrated that the IDO inhibitor drug is useful in mice," says Dr. Munn. "It's useful in a tumor model that is related to the kinds of patients we would want to treat. This brings us closer to being able to approach the FDA suggesting that IDO inhibitor drugs would be appropriate to use in patients."

The National Institutes of Health will do toxicity studies of the IDO inhibitor as well as other studies needed to take the proposal for clinical trials to the Food and Drug Administration, Dr. Munn says.

Should the FDA move toward clinical trials, it likely will be at leas
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
15-Jul-2004


Page: 1 2 3

Related biology news :

1. Protective gene may enhance vaccine responses
2. Protective protein caps discovered at ends of human chromosomes
3. Experimental Staph Vaccine Broadly Protective In Animal Studies
4. Information system to help scientists analyze mechanisms of social behavior
5. Joslin researchers clarify mechanisms for beta-cell formation
6. New mechanism for display of foreign proteins to immune system
7. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
8. Researchers in UGA Vet School discover a mechanism that blocks replication of a retrovirus
9. New genetic mechanism for evolution
10. New research suggests previously unrecognized mechanism by which blood vessels are patterned
11. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... Keck Graduate ... KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded ... of Trustees Chairman Jim Widergren. “He is a great choice to build on the ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
(Date:8/4/2019)... PRINCETON, N.J. (PRWEB) , ... August 02, 2019 ... ... expertise to assist the life science industry in advancing the development of medical ... has been recognized by PharmaVOICE magazine as one of the “100 Most Inspiring ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the recognized ... appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings four ... his healthcare expertise and extensive background in laboratory and scientific products manufacturing, distribution, ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
(Date:8/4/2019)... MINNEAPOLIS (PRWEB) , ... August 02, 2019 , ... Cirtec ... minimally invasive devices, today announced that it has begun construction on a 30,000 sq. ... about 15 miles from San Jose. , The facility, which is expected to ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
Breaking Biology Technology:
Cached News: