HOME >> BIOLOGY >> NEWS
Protein Implicated In Multiple Sclerosis

St. Louis, May 13, 1998 -- Scientists have identified a protein that may trigger the friendly fire that damages nerves in multiple sclerosis (MS). They hope that part of this protein eventually may be useful for therapy.

Immune system cells of MS patients attack the insulating coating around nerve cells in the brain and spinal cord, creating bare patches and scars. Like damaged electrical wires, these nerve cells are unable to transmit impulses efficiently, so patients develop sensory and muscle problems. The coating, called myelin, is made of lipids and proteins.

"For years, researchers have been looking for something in myelin that is more visible to the immune system in MS patients than in healthy people " such a component is likely to be central to the disease," says John L. Trotter, M.D., the Gordon R. and Thelma B. Coates Scholar and professor of neurology at Washington University School of Medicine in St. Louis. "This is the first report of such a substance."

The researchers published their findings in the April issue of the Journal of Neuroimmunology, which will appear mid-May. Trotter is lead author.

Except for trauma, multiple sclerosis is the most common cause of neurological disability among young adults, affecting 250,000 to 350,000 Americans. Depending on where the immune cells attack, the disorder can affect movement, sensation, bladder and bowel control, sexual performance, vision and many other functions.

For the past 40 years, scientists have focused on a myelin component called myelin basic protein, which causes an MS-like disease when injected into animals. But in the 1970s, Trotter became interested in another constituent called myelin proteolipid protein (PLP). It accounts for about half of the protein in myelin and, when injected, also gives animals MS symptoms, Trotter has shown. The protein has been largely ignored, however, because it doesn't dissolve in water and therefor
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
13-May-1998


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... (PRWEB) , ... February 05, 2019 , ... ... technologies, today announced it has partnered with MindFuel, a leading organization in educational ... in K-12 education. Amino Labs has pioneered a syn-bio starter kit ...
(Date:2/2/2019)... ... January 31, 2019 , ... ... has awarded microbiome research support in study design, planning, sample collection, and analysis ... of Obstetrics and Gynecology, and Dr. Sara Vaughn, MD, Reproductive Endocrinology and Infertility ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, the leader ... by A2LA, which establishes requirements for medical laboratories to demonstrate competence to deliver ... CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a designation given to ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... ... January 17, 2019 , ... ... until recently, the exclusive purview of physicians. That's changing as many services now ... to consumer (DTC) laboratory testing market totaled $208 million in 2018, according to ...
(Date:1/15/2019)... ... January 15, 2019 , ... Personalized treatment plans may extend life expectancy for ... a new study published in the journal Radiology. , Kidney, or renal, tumors ... a surgical procedure in which the tumor and part of the kidney are removed. ...
(Date:1/10/2019)... ... ... a local shelter when he was around two years old. According to his mom, ... was adopted, he tore his right cruciate ligament. Though he had his ACL surgically ... injury. , Sure enough, when Rascal was about nine years old, he began showing symptoms ...
(Date:1/8/2019)... ... ... The American Society of Gene and Cell Therapy’s (ASGCT) first ... up of industry leaders identified by the ASGCT board of directors. In total, the ... support ASGCT members designing transformative pilot studies in gene and cell therapy as they ...
Breaking Biology Technology:
Cached News: