HOME >> BIOLOGY >> NEWS
Protein believed to control formation of memory identified by Scripps & UCSD scientists

Scientists at The Scripps Research Institute and the University of California, San Diego (UCSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder.

They found that when the functions of normal CBP is suppressed in adult rodents, the animals had trouble forming long-term memories, suggesting that CBP is required for the formation of long-term memory and that defects in CBP are involved in cognitive dysfunction.

Furthermore, the scientists found that they were able to correct this defect by administering a drug that restored CBP's function.

"This is significant," says Mark Mayford, Ph.D., an associate professor of cell biology and a member of the Institute for Childhood and Neglected Diseases at Scripps Research. Before moving to Scripps Research four years ago, Mayford was a faculty member at UCSD, where together with another UCSD scientist Edward Korzus, Ph.D., they initiated the research.

"There is a link between this molecule and very severe problems in humans," Mayford added, noting that the findings may be significant for children with the rare but severe developmental disorder known as Rubinstein-Taybi syndrome, which causes growth and mental retardation and several anatomical abnormalities. These children have mutations in their CBP genes.

Protein Memories

Scientists have long known that when laboratory animals are treated with a class of drugs known as protein synthesis inhibitors, which stops the production of proteins in the animals' brains, these animals lose their long-term memory. This observation has led scientists to predict that the formation of long-term memory requires new protein synthesis.

This prediction has since been borne out in experiments repeated in many different species -- from mice to fruit flies.
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
23-Jun-2004


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2019)... NEW YORK (PRWEB) , ... December 01, 2019 ... ... identify the latest and greatest tools, technologies, and techniques to hit the life-science ... weighed submissions of innovative products speeding work in laboratories and facilitating biological discovery. ...
(Date:11/27/2019)... ... November 26, 2019 , ... Personalized Stem Cells, Inc ... by the Arthritis Foundation and hosted by Dr. Steven Sampson and Dr. Danielle Aufiero ... place on October 23, 2019, highlighted the ongoing efforts to promote research, educate the ...
(Date:11/20/2019)... ... November 20, 2019 , ... BioInformatics Inc., part of Science and Medicine Group, ... the winners of the Life Science Industry Awards for the most innovative new products ... – Innovation: , Most Innovative New Product – Cell Biology, ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... ... January 07, 2020 , ... Vuja De Sciences (“Vuja De”), a biotechnology startup ... the appointments of Chand Khanna, DVM, PhD, DACVIM (Onc), and Dr. Lee Helman, MD, ... “We are delighted to welcome Chand and Lee as new directors. They will be ...
(Date:12/31/2019)... ... 2019 , ... Vici Health Sciences announces it ... Maryland. Emphasis will be in expanding capabilities in both oral and parenteral dosage ... well positioned to meet the growing demand for its pharmaceutical formulation and analytical ...
(Date:12/27/2019)... ... 2019 , ... Vici Health Sciences is announcing its successful ... offers patients and healthcare providers options in the treatment of chronic diseases that ... and managed care professionals and developed at Vici’s R&D facility in ...
(Date:12/18/2019)... Fla. (PRWEB) , ... December 18, 2019 , ... Tune ... of Advancements, hosted by Ted Danson. Check local listings for more information on this ... innovations in augmented reality are helping to simplify complex system to increase the efficiency, ...
Breaking Biology Technology:
Cached News: