HOME >> BIOLOGY >> NEWS
Protein believed to control formation of memory identified by Scripps & UCSD scientists

Scientists at The Scripps Research Institute and the University of California, San Diego (UCSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder.

They found that when the functions of normal CBP is suppressed in adult rodents, the animals had trouble forming long-term memories, suggesting that CBP is required for the formation of long-term memory and that defects in CBP are involved in cognitive dysfunction.

Furthermore, the scientists found that they were able to correct this defect by administering a drug that restored CBP's function.

"This is significant," says Mark Mayford, Ph.D., an associate professor of cell biology and a member of the Institute for Childhood and Neglected Diseases at Scripps Research. Before moving to Scripps Research four years ago, Mayford was a faculty member at UCSD, where together with another UCSD scientist Edward Korzus, Ph.D., they initiated the research.

"There is a link between this molecule and very severe problems in humans," Mayford added, noting that the findings may be significant for children with the rare but severe developmental disorder known as Rubinstein-Taybi syndrome, which causes growth and mental retardation and several anatomical abnormalities. These children have mutations in their CBP genes.

Protein Memories

Scientists have long known that when laboratory animals are treated with a class of drugs known as protein synthesis inhibitors, which stops the production of proteins in the animals' brains, these animals lose their long-term memory. This observation has led scientists to predict that the formation of long-term memory requires new protein synthesis.

This prediction has since been borne out in experiments repeated in many different species -- from mice to fruit flies.
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
23-Jun-2004


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2019)... ... February 12, 2019 , ... Ava, a 115-pound Newfoundland, found herself in ... of her cruciate ligaments. Just one year later, she suffered the same injury ... recover without surgical intervention and resumed her normal activities without any noticeable pain. ...
(Date:2/6/2019)... CALGARY, Alberta (PRWEB) , ... February 05, 2019 ... ... biology (syn-bio) technologies, today announced it has partnered with MindFuel, a leading organization ... U.S. presence in K-12 education. Amino Labs has pioneered a syn-bio ...
(Date:1/30/2019)... YORK (PRWEB) , ... January ... ... nonprofit organization that identifies, counsels, and supports high-growth, high-impact life science and ... professionals representing 10 national nonprofit disease foundations and disease-focused venture funds to ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... ... January 31, 2019 , ... Signature Matrix and ... perinatal tissue by applied stem cell research expert and Amazon best-selling author, Neil ... a flowable umbilical cord tissue allograft that originates from the same tissue used ...
(Date:2/2/2019)... ... February 01, 2019 , ... Stay on top of current hot topics through ... Access to all webinars is free, so be sure to register today to save ... http://www.xtalks.com to check out our upcoming webinars, or click below to learn more ...
(Date:1/30/2019)... FORT WORTH, Texas (PRWEB) , ... January 29, ... ... of Sales and Marketing with Lifecycle since 2016. In his position as Director ... premier life science tools and services supplier across multiple industries the company supports. ...
(Date:1/30/2019)... ... January 29, 2019 , ... K&R Negotiations announced today that Mladen Kresic, CEO ... event titled: Six Ways to Shorten the Sales Cycle : Reduce Complexity and ... the BrightTALK network. , Negotiation expert Kresic will discuss the realities of today’s ...
Breaking Biology Technology:
Cached News: