HOME >> BIOLOGY >> NEWS
Protein causes muscle wasting syndrome in mice

The Johns Hopkins researchers who first identified myostatin as a key restrictor of muscle growth in animals now report that excessive amounts of the protein in mice cause rapid and dramatic loss of both muscle and fat, without affecting appetite.

The results, obtained by implanting cells engineered to make extra myostatin into adult mice, support the idea of targeting myostatin to find potential new treatments for muscle-wasting diseases like muscular dystrophy, the team from Johns Hopkins and pharmaceutical company Wyeth report in the May 24 issue of Science.

"We now know that myostatin can affect muscle growth and maintenance in adult animals and that it acts throughout the body," says Se-Jin Lee, M.D., Ph.D., professor of molecular biology and genetics in the School of Medicine's Institute for Basic Biomedical Sciences. "These are key pieces of information, because agents interfering with myostatin could only help if the protein normally acts postnatally."

The situation observed in mice is similar to a common and largely untreatable complication of certain cancers, AIDS and other diseases in humans -- extreme loss of both muscle and fat, even while food consumption is normal. However, the researchers caution that it's still unknown whether myostatin is involved in the human wasting syndrome, called cachexia (ka-KEX-ee-a).

"We don't know whether myostatin is a key mediator in human wasting syndromes, but our findings raise the possibility that blocking myostatin activity may have beneficial effects in patients with cachexia," says Teresa Zimmers, Ph.D., who carried out the studies as a graduate student at Hopkins. "At the very least the finding will help clarify aspects of muscle wasting in general."

Previous studies had proved that myostatin normally limits muscle growth; mice without a working myostatin gene develop more muscle than normal mice, making them so-called "mighty mice." Until now the researchers weren't
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
23-May-2002


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
(Date:3/22/2017)... March 21, 2017 Vigilant Solutions , ... law enforcement agencies, announced today the appointment of retired ... of public safety business development. Mr. Sheridan ... experience, including a focus on the aviation transportation sector, ... recent position, Mr. Sheridan served as the Aviation Liaison ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... ... 16, 2017 , ... Zansors has secured a patent ... or EKG) acquisition and monitoring device. This Zansors’ next-generation intellectual property (IP), will ... the skin, making them significantly easier to deploy and use. , Currently, ECG ...
(Date:5/15/2017)... ... May 15, 2017 , ... Tunnell Consulting announced that ... “The Key Role of Specifications in Process Validation,” at the Process Validation Summit ... will bring together leaders from the pharmaceutical and biotech industries to explore processes, strategies ...
(Date:5/12/2017)... , May 12, 2017 GreenMark Biomedical Inc. ... at the 36th annual Michigan Growth Capital Symposium (MGCS) ... Delaware corporation with facilities in ... investors in attendance, including more than 100 top venture ... to society through biobased targeting technologies. GreenMark ...
(Date:5/11/2017)... ... ... The key to unlocking the cause of Multiple Sclerosis may lie in ... that can rob people of their ability to see, speak, and walk. It is ... a genetic tendency towards the disease combined with an unidentified environmental trigger. The genetics ...
Breaking Biology Technology:
Cached News: