Protein component apparently plays key role in muscle elasticity

CHAMPAIGN, Ill. - A pair of hydrogen bonds in the protein titin appears to be a key component allowing muscle to stretch and return to normal by regulating the ability of the protein to unfold one section at a time when stressed, researchers say.

The findings were reported in the Nov. 4 issue of the journal Nature. They are a big step forward in the basic understanding of the protein's role in controlling muscle elasticity, such as in cardiac muscular diseases, said Klaus Schulten, the director of the theoretical biophysics group at the University of Illinois Beckman Institute for Advanced Science and Technology.

Using atomic force microscopes and advanced computer-driven simulations, researchers found that the hydrogen bonds allow all folded subsections (immunoglobulin domains) of titin to stretch by about 6 angstroms and still return to a normal state. Beyond that, the bonds will rupture and domain unfolding occurs. Titin contains roughly 100 immunoglobulin domains, connected like knots on a string; when titin is stretched, the domains unfold one after another, each providing additional length.

The computer simulation allowed the researchers to observe fine mechanical details. When several connected domains are stretched with an atomic force microscope, a graph of the unfolding process displays a hump that disappears as the domains are unfolded. The hump corresponds to the transition of fully folded domains to a newly discovered intermediate state. The simulations identified which hydrogen bonds must break for the transition to occur. "Disruption of these hydrogen bonds eliminates the unfolding intermediate,"said Schulten, the Swanlund Professor of Physics at the U. of I. "The unfolding intermediate can extend the titin by 15 percent of its slack length without causing a complete unraveling of its modules, and hence is likely to be an important component of titin elasticity." At this extension, he added, "the protein will fully unfold if th

Contact: Jim Barlow, Life Sciences Editor
University of Illinois at Urbana-Champaign

Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:

(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a ... awards for not only the products and treatments developed, but also the dedicated ... RF. All the brands built by ABM have received several honors already for ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... biopharmaceutical R&D, today announced that it has entered into a multi-year contract ... (Multiclonics®), to support their translational and clinical research strategy to discover and ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for ... use of mass spectrometry in this field has gained a lot of momentum in ... which approach to use (LBA or MS)?” In many cases, either technology can ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... Mass. (PRWEB) , ... August 11, 2020 , ... ... $300,000 a year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research ... in 2021 and 2022. The network is a consortium of academic research centers ...
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... the leading global provider of advanced delivery technologies, development, and manufacturing solutions for ... they have entered into a strategic partnership whereby Catalent will provide support for ...
(Date:7/18/2020)... ... 16, 2020 , ... After research model surgery and catheter implantation, the long ... only the beginning of a successful study, while protecting and accessing the catheter or ... Head of Surgery from Envigo in a live webinar on ...
Breaking Biology Technology:
Cached News: