HOME >> BIOLOGY >> NEWS
Protein controls acid in cells by direct detection of volume changes, study finds

DALLAS July 5, 2004 A protein responsible for regulating acid levels within cells and pumping out acid accumulated in cardiac cells after a heart attack activates in direct response to changes in a cell's volume, according to a new study by researchers at UT Southwestern Medical Center at Dallas.

Their findings show that the protein NHE1, which is found in the membranes of nearly all cells and is especially active in cancer cells, is regulated by the stretch and pull of the membrane as a cell changes volume. The study appears in the Proceedings of the National Academy of Sciences and is available online.

NHE1, which is called a transporter protein, oscillates its shape rapidly in a cell's membrane. This allows sodium from the outside to come in and protons positively charged particles from inside the cell to escape and lower the cell's acidity. The fewer protons in a cell, the less acidic it is.

"The acidity in the cell is a huge signal for the cell," said Dr. Donald Hilgemann, professor of physiology at UT Southwestern and senior author of the study. "The control of acidity regulates cell growth and proliferation."

Hormones and many other signals that control cell growth and proliferation act on NHE1, he said.

"Our study shows that as cell volume increases, this transporter turns off. If volume decreases, it turns on by directly sensing mechanical changes in the membrane," continued Dr. Hilgemann.

The NHE1 transporter is a protein of much interest to drug developers investigating ways to prevent cell death, which often accompanies heart attacks and strokes. In ischemia, where the blood supply is cut off to cardiac cells or brain cells, cells become very acidic. As the body's normal metabolism gets going again, the NHE1 system starts pumping out the accumulated acid, exchanging the acid for sodium.

"It's such an active system that you can overload the cell with sodium," Dr. Hilgemann said. "Too much sod
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
5-Jul-2004


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein believed to control formation of memory identified by Scripps & UCSD scientists
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global ... of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of ... located in Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical ...
(Date:6/28/2020)... BASEL, Switzerland (PRWEB) , ... ... ... leading provider of enterprise software solutions for biopharmaceutical R&D, today announced that ... oncology company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational ...
(Date:6/25/2020)... (PRWEB) , ... June 24, 2020 , ... ... cloud-based enterprise software and software-driven clinical data services that accelerate drug development, is ... low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SAN FRANCISCO (PRWEB) , ... ... ... fast-growing provider of cloud-based software for the life sciences industry, today announced ... and presentation platform designed specifically for Medical Science Liaisons (MSLs) and other ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign ... detection and prevention of high-burden diseases, and Centric Consulting, a business and technology ... to utilize existing data in order to identify and prioritize patients for care. ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most ... used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate ... Dr MA has been using the zebrafish model to investigate the causes of ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , ... in 2020, despite many obstacles created as a result of COVID-19. As a ... its partnered medical practices and medical manufacturers by expanding access to device offerings, ...
Breaking Biology Technology:
Cached News: