HOME >> BIOLOGY >> NEWS
Protein discovery tied to DNA master switch

(Embargoed) CHAPEL HILL - A new cellular protein discovered by scientists at the University of North Carolina at Chapel Hill appears to be a crucial molecular component of a master switch that turns genes on and off.

The new molecule may prove critical to the regulation of gene expression. If so, it could eventually lead to new treatments for diseases and provide information vital to research aimed at using stem cells to generate organs.

The discovery of the new molecule, SET7, was headed by Dr. Yi Zhang, assistant professor of biochemistry at UNC-CH School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. A report of the research is published in the December 21 issue of the journal Molecular Cell.

All gene expression must be tightly controlled, Zhang said. "When we talk about genes, we're talking about DNA in the cell nucleus that's complexed with several basic proteins called histones. The basic structure is like 'beads on a string' which can be further packaged into a high order structure called chromatin," he explained.

"This chromatin packaging allows for efficient storage of genetic information. But it also impedes access to DNA by transcription factors, proteins that regulate gene expression."

Zhang and his colleagues believe their discovery to be part of the mechanism that dynamically changes the chromatin structure, its loosening or tightening. They focused their attention on a particular covalent modification -- methylation, addition of a methyl group to lysine, one of the amino acids that comprise the tail domain of the histone molecules.

Why lysine? Because recent research had linked gene silencing, or deactivation, to methylation of a particular lysine site (lysine 9) on the tail of the histone H3.

As it turns out, modifications of amino acids by methylation mainly occur on lysine. "We've known for three decades that histone can be methylated, but nobody knew the
'"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
20-Dec-2001


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
(Date:8/26/2020)... ... August 25, 2020 , ... Catalent, the leading global ... and gene therapies, and consumer health products, today announced that two Catalent Biologics ... Expo, taking place between Aug. 31 – September 4, 2020. , On Wednesday, ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. ... the X-ray analysis community, presenting current news and crystallographic research. , The ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... 2020 , ... Medial EarlySign , a leader in ... high-burden diseases, and Centric Consulting, a business and technology consulting firm, today announced ... in order to identify and prioritize patients for care. , Combining Centric’s management ...
(Date:7/10/2020)... KONG (PRWEB) , ... July 09, 2020 , ... ... compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish ... the PolyU research team led by Dr MA has been using the zebrafish ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... growth of 40% in 2020, despite many obstacles created as a result of ... increase revenue for its partnered medical practices and medical manufacturers by expanding access ...
Breaking Biology Technology:
Cached News: