HOME >> BIOLOGY >> NEWS
Protein fishing in America: The movie

PHILADELPHIA--Proteins pass messages to other proteins much like fly-fishermen flicker their lines against water, or so a current leading theory holds. The repeated weak slapping of protein surfaces against one-another is the critical first step in a chain of events that rule all subsequent cellular behavior.

But this vital exchange between single molecules has defied direct observation because that line-flicking and message-passing happen randomly at such a small scale.

A Pacific Northwest National Laboratory team led by H. Peter Lu, using a technique called single-molecule photon stamping spectroscopy, has now observed real-time interactions of single proteins. Their experimental evidence, reported Thursday at the 228th national meeting of the American Chemical Society, supports the fly-fishing theory of protein communication.

"In the past five years, the field of protein-protein interaction dynamics has exploded," said Lu, a staff scientist at the Department of Energy laboratory in Richland, Wash. "Measurements to date have been snapshots of proteins. But to do dynamic measurements, to capture proteins in motion, this is unique."

Techniques such as nuclear magnetic resonance and x-ray crystallography reveal structural details about proteins and positions of their atoms at a particular time in space. They provide structural reference points, but to contrive interactions, many images have to be gathered at different times, events averaged out and a narrative flow imposed. The effect is akin to cutting a cartoon into a thousand frames tossing the pieces from the ceiling like confetti, then gathering them off the floor and reassembling them. Try making sense of that.

"It's not an observation in real time," Lu said. "You're measuring many proteins at a time, and you get information about two states and two states only: binding or not binding. How the binding and not binding are linked is hidden information." Lu's single-molec
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
26-Aug-2004


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
6. Protein key to trafficking in nerve terminals
7. Protein controls acid in cells by direct detection of volume changes, study finds
8. Protein believed to control formation of memory identified by Scripps & UCSD scientists
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... (PRWEB) , ... November 19, 2019 , ... ... research and sample preparation, and Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a ... partnership in which Diagenode will offer Single-Cell ATAC-Seq (scATAC-Seq) Services, featuring Bio-Rad’s Droplet ...
(Date:11/19/2019)... N.Y. (PRWEB) , ... November 19, 2019 , ... Hosted ... MJBizDaily , MJBizCon 2019 is the largest gathering of MJBiz business ... exceeding 35,000, and programming to benefit every sector, there is no show quite like ...
(Date:11/14/2019)... (PRWEB) , ... November 13, 2019 , ... Personalized ... the first patients in an FDA approved clinical trial for stem cell treatment ... the formation of the company as a subsidiary of VetStem Biopharma. , In July ...
Breaking Biology News(10 mins):
(Date:12/27/2019)... ELKRIDGE, Md. (PRWEB) , ... December 27, 2019 ... ... of initial clinical studies for its 505(b)(2) product pipeline that offers ... affect geriatric patients. The products concepts were identified in collaboration with doctors and ...
(Date:12/14/2019)... ... December 12, 2019 , ... Leak Detection Associates (LDA) ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is excited to announce ... -80C) helium leak testing system is designed for testing containers at temperatures as ...
(Date:12/4/2019)... ... December 03, 2019 , ... A new study released today in STEM ... even reverse fibrosis (scar tissue) buildup – also improves the range of motion of ... was conducted on mice. , The tumor-destroying capabilities of radiation therapy can be ...
(Date:11/22/2019)... ... November 22, 2019 , ... ... covering a step-by-step cold chain validation guide to meet and exceed increasingly ... complex cold chain biopharmaceutical industry leaders, the September 19, 2019 webinar was ...
Breaking Biology Technology:
Cached News: