HOME >> BIOLOGY >> NEWS
Protein found in yeast and humans appears to play a key role in regulating cell growth

What do humans have in common with yeast -- that lowly, single-celled organism known best for its role in making beer and bread?

Plenty, according to researchers at Seattle's Fred Hutchinson Cancer Research Center, who have found that humans and yeast share a protein that appears to play a key role in regulating cell growth.

Ronald Reeder, Ph.D., a member of the Hutchinson Center's Basic Sciences Division, heads the group that published the results of this work earlier this week in the Proceedings of the National Academy of Sciences (Early Edition No. 12). Co-authors on the paper are research associate Beth Moorefield, Ph.D., and biocomputing specialist Elizabeth Greene, Ph.D., both of the Hutchinson Center. The protein, called Rrn3, may play a pivotal role in the chain of events that determines how fast cells grow.

"For a protein to be functionally conserved from yeast all the way up to humans implies there must be a reason that it has been preserved from an evolutionary standpoint," Reeder says. "We know that if you don't have this protein, you don't grow. Even if there are other mechanisms that human cells use to regulate cell growth, the fact that this one is so well conserved in humans means it's an important piece of the puzzle in our understanding of growth control."

While Reeder and colleagues are primarily excited about this fundamental new understanding of the molecular mechanisms that trigger cell growth, the discovery that Rrn3 functions in humans as well as yeast may have several long-range benefits.

This regulatory molecule may be a unique drug target, as disabling it might halt the growth of cancer cells. The protein also might be used as a biomarker to develop highly sensitive cancer-screening methods, as the activity of Rrn3 is expected to mirror the rate of cell growth throughout the body.

"If you were looking at the thymus or the liver, for example, and wanted to distinguish cells that were doing normal things vs. ce
'"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
13-Apr-2000


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... applications consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding ... offers a broad range of contract analysis services for advanced applications. Services ...
(Date:10/6/2017)... Mass. (PRWEB) , ... October 06, 2017 , ... ... female entrepreneurship within the healthcare and technology sector at their fourth annual Conference ... panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage ...
(Date:10/5/2017)... Philadelphia, PA (PRWEB) , ... October 05, 2017 , ... ... of the newest frontiers in human health. Gut Love: You Are My Future, the ... offers an artist’s perspective as it explores the human condition through the lens of ...
Breaking Biology Technology:
Cached News: