HOME >> BIOLOGY >> NEWS
Protein involved in childhood disorder linked to cancer

A team of scientists has found that a protein involved in a congenital neurological disorder also plays a role in DNA damage repair and thus cancer prevention.

The research appears as the "Paper of the Week" in the August 13 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Primary microcephaly is a rare neurological disorder that results in an abnormally small head due to improper brain formation and growth. Children with this condition may be short, have seizures and have normal or mildly retarded intelligence.

"Microcephalin is the protein encoded by the MCPH1 gene, which, when mutated, is a major cause of microcephaly. We have now identified an important function for microcephalin, which may eventually help explain the connection of MCPH1 with microcephaly, and which links microcephalin function to DNA damage responses that prevent cancer from developing," said David F. Stern, Ph.D., and Xingzhi Xu, M.D./Ph.D. of the Yale University School of Medicine.

Cells incur chronic DNA damage from exposure to normal metabolic byproducts as well as external chemicals and radiation. In order to mitigate this DNA damage, cells must have a mechanism for both detecting damage and for stopping their machinery until the damage is fixed. This feedback mechanism relies on cycle "checkpoint" controls that delay the cell division cycle so that these repair systems have time to work.

"Regulation of these protective processes is coordinated through the action of signaling systems that detect DNA damage, interpret and amplify the signal, and call in appropriate repair and checkpoint responses," said Stern and Xu. "Impairment of checkpoint signaling systems can lead to excessive accumulation of mutations or chromosomal aberrations that are an important aspect of human carcinogenesis."

Microcephalin is very similar in structure to several "mediator" proteins known to b
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
31-Aug-2004


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein fishing in America: The movie
5. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
6. Protein key to trafficking in nerve terminals
7. Protein controls acid in cells by direct detection of volume changes, study finds
8. Protein believed to control formation of memory identified by Scripps & UCSD scientists
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein involved childhood disorder linked cancer

(Date:7/30/2014)... tended her eggs until they hatched 4.5 years later, ... the open-access journal PLOS ONE by Bruce ... , Octopuses typically have a single reproductive period during ... of their fertilized eggs until they hatch. Shallow-water octopuses ... months, but little is known about the brooding of ...
(Date:7/30/2014)... effects of climate change on the world,s animal ... factors, according to a new paper by a ... of Queensland, and other organizations. The authors claim ... the point when it comes to climate change. ... scientists focus on the "direct" threats of changing ...
(Date:7/30/2014)... Board of the Entomological Society of America (ESA) has ... The election as a Fellow acknowledges outstanding contributions to ... teaching, extension, or administration. The following Fellows will be ... -- which will be held November 16-19, 2014 in ... is a professor with the Department of Plant, Soil ...
Breaking Biology News(10 mins):Deep-sea octopus has longest-known egg-brooding period 2Conservation scientists asking wrong questions on climate change impacts on wildlife 2Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17
(Date:7/31/2014)... July 31, 2014 CollabRx, Inc. (NASDAQ: ... therapeutic decision-making in oncology, today announced that it will ... to discuss the Company's financial results for the first ... about the business in the current fiscal year. , ... on Thursday, August 14, 2014, at 5 p.m. EDT ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... “Rapid technological advances will spread a ... unemployment, depressing American consumer spending and further shrinking ... 22—we need automated manufacturing if we are to ... economist and corporate relocation expert Dr. Ron Pollina ... States for 2014, co-published with the American Economic ...
(Date:7/31/2014)... Boston’s Adult Stem Cell Technology Center, LLC ( ... cell biotechnologies. Currently the company holds seven recently ... applications currently under examination by the U.S. Patent and ... the most vexing problems in adult stem cell biology ... difficult to identify; and they have been difficult to ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
Cached News: