HOME >> BIOLOGY >> NEWS
Protein involved in childhood disorder linked to cancer

A team of scientists has found that a protein involved in a congenital neurological disorder also plays a role in DNA damage repair and thus cancer prevention.

The research appears as the "Paper of the Week" in the August 13 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Primary microcephaly is a rare neurological disorder that results in an abnormally small head due to improper brain formation and growth. Children with this condition may be short, have seizures and have normal or mildly retarded intelligence.

"Microcephalin is the protein encoded by the MCPH1 gene, which, when mutated, is a major cause of microcephaly. We have now identified an important function for microcephalin, which may eventually help explain the connection of MCPH1 with microcephaly, and which links microcephalin function to DNA damage responses that prevent cancer from developing," said David F. Stern, Ph.D., and Xingzhi Xu, M.D./Ph.D. of the Yale University School of Medicine.

Cells incur chronic DNA damage from exposure to normal metabolic byproducts as well as external chemicals and radiation. In order to mitigate this DNA damage, cells must have a mechanism for both detecting damage and for stopping their machinery until the damage is fixed. This feedback mechanism relies on cycle "checkpoint" controls that delay the cell division cycle so that these repair systems have time to work.

"Regulation of these protective processes is coordinated through the action of signaling systems that detect DNA damage, interpret and amplify the signal, and call in appropriate repair and checkpoint responses," said Stern and Xu. "Impairment of checkpoint signaling systems can lead to excessive accumulation of mutations or chromosomal aberrations that are an important aspect of human carcinogenesis."

Microcephalin is very similar in structure to several "mediator" proteins known to b
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
31-Aug-2004


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein fishing in America: The movie
5. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
6. Protein key to trafficking in nerve terminals
7. Protein controls acid in cells by direct detection of volume changes, study finds
8. Protein believed to control formation of memory identified by Scripps & UCSD scientists
9. Protein stops blood-vessel growth, holds promise as cancer therapy
10. Proteins transform DNA into molecular velcro
11. Protein engineered to detect nerve gas

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein involved childhood disorder linked cancer

(Date:12/17/2014)... DUBLIN , Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home Button ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first time ...
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in this market ... applications. Chemical sensors help in recording of patient data ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
(Date:12/24/2014)... GMO corn cases filed across the United States, ... of being consolidated in a Kansas federal court for pretrial ... 162 Corn Litigation, MDL No. 2591 in the U.S. District ... Syngenta GMO corn multidistrict litigation (MDL) has been handed over ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... According to Ross Selinger, President of Selinger ... the national office market continues to be strong, driven by ... by the third quarter’s surprising 3.9% GDP, unemployment decreasing to ... have held inflation down and the Fed is keeping interest ...
(Date:12/24/2014)... 23, 2014 Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading professional ... In his new role as treasurer, Dr. Hill also ... a voice in furthering the mission of ASRM. , ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
Cached News: