HOME >> BIOLOGY >> NEWS
Protein may reduce susceptibility to autoimmune disease

A recent discovery provides new information about critical cellular signals that may be involved in autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Scientists have identified a protein that appears to regulate the function of the immune cells, called T cells, which contribute to the pathogenesis associated with autoimmune disease. The research is published in the May issue of Immunity.

Cytotoxic T lymphocytes are immune cells that normally protect the body from infection by destroying cancer cells and cells infected with dangerous bacteria or viruses. However, overactivation of T cells can lead to an assault on the body's own healthy tissues, leading to some form of autoimmune disease. The protein cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is well known as an important regulator of the immune system and plays a critical role in down-regulating T cell responses.

Dr. Linda S. Wicker from the Cambridge Institute for Medical Research and Dr. Vijay K. Kuchroo from the Center for Neurologic Diseases at Brigham and Women's Hospital and Harvard Medical School examined the function of a newly discovered naturally occurring form of CTLA-4 called ligand independent CTLA-4 (liCTLA-4) because low levels of this alternate form of CTLA-4 have been associated with autoimmune disease susceptibility.

The researchers found that liCTLA-4 is present in T cells and vigorously inhibits T cell responses. There was an enhanced expression of liCTLA-4 protein in the T cells of a special strain of mice that is resistant to type 1 diabetes compared to a strain of the mice that is susceptible to the disease.

The researchers conclude that increased expression of liCTLA-4 reduces activation of T cells and thus plays a role in preventing susceptibility to T cell-mediated autoimmune diseases. "The discovery of a new form of CTLA-4 was a completely unexpected result and demonstrates that the study of natural va
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
18-May-2004


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for the ... of Care Testing solutions (POCT). Check local listings for more info. , Today, the ... and are shipped to labs throughout the country. Results are then available several days ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable energy ... operations in the fight against the COVID-19 pandemic in Zambia. , One of ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... In its ... feature interview with Dr. James L. Sherley, M.D., Ph.D., founder and director of ... the company announced on June 16 that starting July 5 it would ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 25, 2020 , ... With ... a vaccine or drug treatment. In an effort to better understand the cellular ... the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis Corporation, the premier provider ... Derek Fournier has been appointed CEO and President. Founder and former CEO, David ... , “DeCurtis Corporation has been on an incredible journey for the last twenty ...
(Date:6/19/2020)... Russia (PRWEB) , ... June 18, 2020 , ... The ... 2018. Its goal is to join forces to radically prolong life and find a ... postpone the aging period. This project was supported by various scientists from all over ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has been and will continue ... to stock market dips, ways to reduce CO2 is something we can’t avoid. ... of the biofuels being produced today are created from recycled cooking oil or crops. ...
Breaking Biology Technology:
Cached News: